Izvorni znanstveni članak
Hyperleptinemia – Non-Haemodynamic Risk Factor for the Left Ventricular Hypertrophy Development in Hypertensive Overweight Females
Kristina Selthofer-Relatić
Radivoje Radić
Vedrana Vizjak
Aleksandar Včev
Pašezada Kosović
Ivica Bošnjak
Robert Selthofer
Sažetak
Obesity is directly and strongly associated with hypertension and left ventricular hypertrophy (LVH). Development of
LVH is multifactorial, caused both by haemodynamic and non-haemodynamic factors. Hypertension is the main haemodynamic
factor. Humoral mechanisms, as a non-haemodynamic factor for LVH development, have not been completely
explained. The aim of this study is to determine whether hyperleptinemia can be one of humoral – non-haemodynamic
factor inducing LVH together with haemodynamic factors in overweight females. The study was done on thirty six adult,
overweight female patients, body mass index in range 25–30 kg/m2. Patients are nondiabetic with regular renal function.
Twenty one female patients were hypertensive with left ventricular hypertrophy. Control group included fifteen hypertensive
female patients without left ventricular hypertrophy. In all patients was determined glucose profile and creatinine
clearance, cholesterol, triglycerides, LDL, HDL.Weight, high, circumference of the waist and hips was taken. Cardiovascular
determination was done applying two-dimensional ultrasound. Serum leptin level was measured using radioimmunoassay
method (RIA). Results showed that serum leptin level was significantly higher in hypertensive, overweight
females with LVH. This suggests that non-haemodynamic factors, such as hyperleptinemia, participate in left ventricular
hypertrophy development together with haemodynamic factors in adult hypertonic, overweight females.
Ključne riječi
leptin; obesity; hypertension; left ventricular hypertrophy
Hrčak ID:
27066
URI
Datum izdavanja:
2.9.2008.
Posjeta: 1.036 *