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Association of Angiotensin-Converting Enzyme Insertion-Deletion Polymorphism with Preeclampsia

Berivoj Mišković
Jadranka Sertić
Ana Stavljenić-Rukavina
Feodora Stipoljev

Puni tekst: engleski, pdf (68 KB) str. 339-343 preuzimanja: 371* citiraj
APA 6th Edition
Mišković, B., Sertić, J., Stavljenić-Rukavina, A. i Stipoljev, F. (2008). Association of Angiotensin-Converting Enzyme Insertion-Deletion Polymorphism with Preeclampsia. Collegium antropologicum, 32 (2), 339-343. Preuzeto s https://hrcak.srce.hr/27202
MLA 8th Edition
Mišković, Berivoj, et al. "Association of Angiotensin-Converting Enzyme Insertion-Deletion Polymorphism with Preeclampsia." Collegium antropologicum, vol. 32, br. 2, 2008, str. 339-343. https://hrcak.srce.hr/27202. Citirano 13.11.2019.
Chicago 17th Edition
Mišković, Berivoj, Jadranka Sertić, Ana Stavljenić-Rukavina i Feodora Stipoljev. "Association of Angiotensin-Converting Enzyme Insertion-Deletion Polymorphism with Preeclampsia." Collegium antropologicum 32, br. 2 (2008): 339-343. https://hrcak.srce.hr/27202
Harvard
Mišković, B., et al. (2008). 'Association of Angiotensin-Converting Enzyme Insertion-Deletion Polymorphism with Preeclampsia', Collegium antropologicum, 32(2), str. 339-343. Preuzeto s: https://hrcak.srce.hr/27202 (Datum pristupa: 13.11.2019.)
Vancouver
Mišković B, Sertić J, Stavljenić-Rukavina A, Stipoljev F. Association of Angiotensin-Converting Enzyme Insertion-Deletion Polymorphism with Preeclampsia. Collegium antropologicum [Internet]. 2008 [pristupljeno 13.11.2019.];32(2):339-343. Dostupno na: https://hrcak.srce.hr/27202
IEEE
B. Mišković, J. Sertić, A. Stavljenić-Rukavina i F. Stipoljev, "Association of Angiotensin-Converting Enzyme Insertion-Deletion Polymorphism with Preeclampsia", Collegium antropologicum, vol.32, br. 2, str. 339-343, 2008. [Online]. Dostupno na: https://hrcak.srce.hr/27202. [Citirano: 13.11.2019.]

Sažetak
The aim of this study was to determine if insertion-deletion polymorphism of angiotensin-converting enzyme is a risk
factor for the development of preeclampsia. Sixty women with preeclampsia and 50 normotensive pregnant women were
included in this study. Preeclampsia was defined as blood pressure > 140/90 mmHg in a previously normotensive women
with proteinuria >300 mg/L in a 24-hours. Twelve women also had preeclampsia in previous pregnancy. The genotyping
of polymorphism in the intron 16 of the angiotensin-converting enzyme was performed by the polymerase chain reaction
followed by the agarose electrophoresis. The patients were divided into three groups according to the presence (I)
or absence (D) of insertional polymorphism (II, ID, and DD). Genotype distribution and allele frequencies were compared
by Mantel-Haenszel c
2 testing. The frequency of DD genotype was not significantly higher in women with preeclampsia
(26/60)than in the control group (14/50, p=0.096). The D allele frequency was significantly higher in 17 women with
preeclampsias who required delivery before 34 weeks of pregnancy (0.735), than in 43 women in whom obstetric complications
took place after 34 weeks of pregnancy (0.56, p=0.036). The D allele frequency was 0.83 in women having recurrent
preeclampsia, i.e. significantly higher compared with women, who were for the first time, experienced preeclampsia
(0.57, p=0.013). This study showed a significantly positive association between D allele frequency and risk of recurrent
preeclampsia and preterm delivery before 34 weeks of pregnancy. The deletion genotype could be an important contributing
factor for an early onset and recurrent preeclampsia.

Ključne riječi
preeclampsia; Caucasians; renin-angiotensin system; gene; polymorphism

Hrčak ID: 27202

URI
https://hrcak.srce.hr/27202

Posjeta: 517 *