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Original scientific paper

The Mechanisms of UV Radiation in the Development of Malignant Melanoma

Mirna Šitum
Marija Buljan
Suzana Ožanić Bulić
Dubravka Šimić

Fulltext: english, pdf (85 KB) pages 13-16 downloads: 939* cite
APA 6th Edition
Šitum, M., Buljan, M., Ožanić Bulić, S. & Šimić, D. (2007). The Mechanisms of UV Radiation in the Development of Malignant Melanoma. Collegium antropologicum, 31 - Supplement 1 (1), 13-16. Retrieved from https://hrcak.srce.hr/27414
MLA 8th Edition
Šitum, Mirna, et al. "The Mechanisms of UV Radiation in the Development of Malignant Melanoma." Collegium antropologicum, vol. 31 - Supplement 1, no. 1, 2007, pp. 13-16. https://hrcak.srce.hr/27414. Accessed 20 Nov. 2019.
Chicago 17th Edition
Šitum, Mirna, Marija Buljan, Suzana Ožanić Bulić and Dubravka Šimić. "The Mechanisms of UV Radiation in the Development of Malignant Melanoma." Collegium antropologicum 31 - Supplement 1, no. 1 (2007): 13-16. https://hrcak.srce.hr/27414
Harvard
Šitum, M., et al. (2007). 'The Mechanisms of UV Radiation in the Development of Malignant Melanoma', Collegium antropologicum, 31 - Supplement 1(1), pp. 13-16. Available at: https://hrcak.srce.hr/27414 (Accessed 20 November 2019)
Vancouver
Šitum M, Buljan M, Ožanić Bulić S, Šimić D. The Mechanisms of UV Radiation in the Development of Malignant Melanoma. Collegium antropologicum [Internet]. 2007 [cited 2019 November 20];31 - Supplement 1(1):13-16. Available from: https://hrcak.srce.hr/27414
IEEE
M. Šitum, M. Buljan, S. Ožanić Bulić and D. Šimić, "The Mechanisms of UV Radiation in the Development of Malignant Melanoma", Collegium antropologicum, vol.31 - Supplement 1, no. 1, pp. 13-16, 2007. [Online]. Available: https://hrcak.srce.hr/27414. [Accessed: 20 November 2019]

Abstracts
The sunlight was one of the first agents recognized to be carcinogenic for humans. There is convincing evidence from
epidemiologic studies that exposure to solar radiation is the major cause of cutaneous melanoma in light-pigmented populations
and plays a role in the increasing incidence of this malignancy. The molecular mechanisms by which UV radiation
exerts its varied effects are not completely understood, however, it is considered that UVA and UVB are equally critical
players in melanoma formation. Whereas UVA can indirectly damage DNA through the formation of reactive oxygen
radicals, UVB can directly damage DNA causing the apoptosis of keratinocytes by forming the sunburn cells. Besides action
through mutations in critical regulatory genes, UV radiation may promote cancer through indirect mechanisms,
e.g. immunosuppression and dysregulation of growth factors. The carcinogenic process probably involves multiple sequential
steps, some, but not all of which involve alterations in DNA structure.

Keywords
melanoma; UV radiation; photoimmunology; oncogene

Hrčak ID: 27414

URI
https://hrcak.srce.hr/27414

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