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Original scientific paper

Expression of Cell Cycle and Apoptosis Regulatory Proteins and Telomerase in Melanocitic Lesions

Tanja Batinac
Ita Hadžisejdić
Gordana Brumini
Alen Ružić
Božidar Vojniković
Gordana Zamolo

Fulltext: english, pdf (197 KB) pages 17-22 downloads: 334* cite
APA 6th Edition
Batinac, T., Hadžisejdić, I., Brumini, G., Ružić, A., Vojniković, B. & Zamolo, G. (2007). Expression of Cell Cycle and Apoptosis Regulatory Proteins and Telomerase in Melanocitic Lesions. Collegium antropologicum, 31 - Supplement 1 (1), 17-22. Retrieved from https://hrcak.srce.hr/27415
MLA 8th Edition
Batinac, Tanja, et al. "Expression of Cell Cycle and Apoptosis Regulatory Proteins and Telomerase in Melanocitic Lesions." Collegium antropologicum, vol. 31 - Supplement 1, no. 1, 2007, pp. 17-22. https://hrcak.srce.hr/27415. Accessed 9 Aug. 2020.
Chicago 17th Edition
Batinac, Tanja, Ita Hadžisejdić, Gordana Brumini, Alen Ružić, Božidar Vojniković and Gordana Zamolo. "Expression of Cell Cycle and Apoptosis Regulatory Proteins and Telomerase in Melanocitic Lesions." Collegium antropologicum 31 - Supplement 1, no. 1 (2007): 17-22. https://hrcak.srce.hr/27415
Harvard
Batinac, T., et al. (2007). 'Expression of Cell Cycle and Apoptosis Regulatory Proteins and Telomerase in Melanocitic Lesions', Collegium antropologicum, 31 - Supplement 1(1), pp. 17-22. Available at: https://hrcak.srce.hr/27415 (Accessed 09 August 2020)
Vancouver
Batinac T, Hadžisejdić I, Brumini G, Ružić A, Vojniković B, Zamolo G. Expression of Cell Cycle and Apoptosis Regulatory Proteins and Telomerase in Melanocitic Lesions. Collegium antropologicum [Internet]. 2007 [cited 2020 August 09];31 - Supplement 1(1):17-22. Available from: https://hrcak.srce.hr/27415
IEEE
T. Batinac, I. Hadžisejdić, G. Brumini, A. Ružić, B. Vojniković and G. Zamolo, "Expression of Cell Cycle and Apoptosis Regulatory Proteins and Telomerase in Melanocitic Lesions", Collegium antropologicum, vol.31 - Supplement 1, no. 1, pp. 17-22, 2007. [Online]. Available: https://hrcak.srce.hr/27415. [Accessed: 09 August 2020]

Abstracts
To gain insight into the role and association of cell cycle and apoptosis regulatory proteins and telomerase activity in
the course of progression of melanocitic lesions we have examined immunohistochemicaly, expression and the distribution
of p53, bcl-2, Ki-67 and telomerase in 25 samples of common and dysplastic nevi, and 45 samples of primary invasive
melanomas. Protein p53 expression was significantly increased in dysplastic as compared with common nevi and
melanomas (p<0.001). Bcl-2 protein expression was significantly increased in melanomas as compared with common
aquired and dysplastic nevi (p=0.001). Nevi and melanomas exhibited clear-cut differences in terms of Ki-67 expression.
Telomerase expression was significantly increased in melanomas as compared with common acquired (p=0.014) and
dysplastic nevi (p<0.001). Enhanced telomerase activity in association with increased bcl-2 expression in the course of
melanoma progression could contribute to development and progression of melanoma.

Keywords
bcl-2; melanoma; nevi; telomerase

Hrčak ID: 27415

URI
https://hrcak.srce.hr/27415

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