Izvorni znanstveni članak
Progressive Chronic Inflammatory Demyelinating Polyneuropathy in a Child with Central Nervous System Involvement and Myopathy
Nina Barišić
Rita Horvath
Lana Grković
Dina Mihelčić
Tomislav Luetić
Sažetak
Chronic inflammatory demyelinating polyneuropathy (CIDP) is a chronic disorder, manifesting with monophasic or
relapsing course. Progressive course is rare in children. The article presents a boy with progressive generalized muscle
weakness and areflexia since the age of two, developed after viral infection. Electromyoneurography showed severe neurogenic
lesion, with myopathic pattern in proximal muscles. Increased serum ganglioside antibody titers (anti-GM1
and anti-GD1b) were registered. Sural nerve biopsy revealed demyelination and onion bulbs. Inflammatory perivascular
CD3 positive infiltrates were present in muscle and nerve biopsies. Brain magnetic resonance imaging showed cortical
atrophy, hyperintensities of the white matter and gray matter hypointensities. Improvement occurred on intravenous immune
globulins and methylprednisolone treatment. Demyelination might develop in central and peripheral nervous system
associated with inflammatory myopathy in patients with progressive course of CIDP.
Ključne riječi
chronic inflammatory demyelinating polyneuropathy; inflammatory myopathy; central nervous system; child; antiganglioside antibody
Hrčak ID:
27633
URI
Datum izdavanja:
13.12.2006.
Posjeta: 1.862 *