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Of Mice and Men: Teratomas and Teratocarcinomas

Floriana Bulić-Jakuš
Monika Ulamec
Maja Vlahović
Nino Sinčić
Ana Katušić
Gordana Jurić-Lekić
Ljiljana Šerman
Božo Krušlin2
Mladen Belicza

Puni tekst: engleski, pdf (99 KB) str. 921-924 preuzimanja: 1.007* citiraj
APA 6th Edition
Bulić-Jakuš, F., Ulamec, M., Vlahović, M., Sinčić, N., Katušić, A., Jurić-Lekić, G., ... Belicza, M. (2006). Of Mice and Men: Teratomas and Teratocarcinomas. Collegium antropologicum, 30 (4), 921-924. Preuzeto s
MLA 8th Edition
Bulić-Jakuš, Floriana, et al. "Of Mice and Men: Teratomas and Teratocarcinomas." Collegium antropologicum, vol. 30, br. 4, 2006, str. 921-924. Citirano 20.01.2021.
Chicago 17th Edition
Bulić-Jakuš, Floriana, Monika Ulamec, Maja Vlahović, Nino Sinčić, Ana Katušić, Gordana Jurić-Lekić, Ljiljana Šerman, Božo Krušlin2 i Mladen Belicza. "Of Mice and Men: Teratomas and Teratocarcinomas." Collegium antropologicum 30, br. 4 (2006): 921-924.
Bulić-Jakuš, F., et al. (2006). 'Of Mice and Men: Teratomas and Teratocarcinomas', Collegium antropologicum, 30(4), str. 921-924. Preuzeto s: (Datum pristupa: 20.01.2021.)
Bulić-Jakuš F, Ulamec M, Vlahović M, Sinčić N, Katušić A, Jurić-Lekić G i sur. Of Mice and Men: Teratomas and Teratocarcinomas. Collegium antropologicum [Internet]. 2006 [pristupljeno 20.01.2021.];30(4):921-924. Dostupno na:
F. Bulić-Jakuš, et al., "Of Mice and Men: Teratomas and Teratocarcinomas", Collegium antropologicum, vol.30, br. 4, str. 921-924, 2006. [Online]. Dostupno na: [Citirano: 20.01.2021.]

Teratomas and teratocarcinomas are tumors containing tissue derivatives of all three germ-layers. They can be induced
by transplantation of animal embryos to ectopic microenvironment. Development of malignant teratocarcinomas
depends on embryonic stage, species-specificity and immunological competence of the host. In the man, teratomas and
teratocarcinomas usually represent a subtype of germ-cell tumors but sacrococcygeal teratomas arise from the remnants
of the pluripotent primitive streak. Undifferentiated embryonal carcinoma (EC) cells are responsible for the malignancy
of experimental mouse teratocarcinomas. Mouse EC cells injected to the adult give rise to tumors and upon injection to
early embryos to differentiated tissues – thus resembling normal mouse embryonic stem cells (mESC). Epigenetic changes
rather than mutations are associated with transformation of mESC to EC cells. Human EC and ES cell-lines (hESC)
contain chromosomal abnormalities and can form teratocarcinoma after transplantation. ES cells are among those proposed
for cell replacement therapy in the man. Suicide gene introduction should be recommended prior to their use in
vivo to ablate them in case of malignant transformation.

Ključne riječi
teratoma; teratocarcinoma; embryo; EC cell; ES cell; cell therapy

Hrčak ID: 27640


Posjeta: 1.252 *