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Interleukin-1 Production in Human Corneal Scars
Iva Dekaris
Nikica Gabrić
Damir Bosnar
Alenka Gagro
Alemka Markotić
Ratimir Lazić
Sažetak
We studied IL-1 level in corneal scars with/without neo-vascularization. A total of 27 patients underwent grafting
for corneal scar. Recipients were grouped according to number of vascularized quadrants (0 to IV/IV): none (n=12), one
(n=5), two (n=4) and four (n=6). Recipient corneas were collected during surgery and IL-1 measured by immunoassay.
Controls were donor corneas unsuitable for transplantation. Graft rejection rate was calculated for each group.
Mean IL-1 concentration in corneal scars was 63.93 pg/mm3; significantly higher as compared to controls (1.25
2.03 pg/mm3). IL-1 correlated well with amount of blood vessels, except in IV/IV scars: 5.173.65 pg/mm3 for 0/IV;
8.022.51 pg/mm3 for I/IV; 8.273.62 pg/mm3 for II/IV and 4.475.03 pg/mm3 for IV/IV corneal scars. Vascularization
of corneal scar is associated with increased IL-1 level (in all but highly vascularized scars), indicating that
IL-1 promotes early stages of vascularization. Graft rejection rate increases in patients with higher vascularization,
independently of IL-1 level.
Ključne riječi
Interleukin-1; scars; cornea; humans
Hrčak ID:
27886
URI
Datum izdavanja:
20.6.2005.
Posjeta: 893 *