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Premature Parental Heart Attack is Heralding Elevated Risk in Their Offspring
Mirjana Rumboldt
Zvonko Rumboldt
Serafina Pesenti
Sažetak
A small subgroup of children, whose parents have suffered a heart attack in their
late thirties and early forties, may be at particularly high cardiovascular risk. University
Hospital »Split« gives tertiary health care to some 700,000 people in southern Croatia
and treats about 300 acute myocardial infarctions per year, with a 3–5% share in the
age under 45 years. This cross-sectional, clinical and laboratory study included all the
patients below the age limit of 45 years, treated for acute myocardial infarction between
1990 and 1995, complexively 55 of them, and their natural children, 97 all in all. The
results were compared to those of a stratified children's sample taken from the population
of the same region. The relative weight, blood pressure, and plasma cholesterol
were significantly higher in these children than in the control group (p < 0.05). In 50 of
these offspring (51.5%), in addition to the obviously positive family history, detected
were further cardiovascular risk factors, defined as values above the 95th distribution
percentile for age and gender. The average blood pressure, relative weight and cholesterol
levels were even higher in these, »risky« children than in the studied sample (p < 0.05),
and much more elevated than in the matching control pupils (p < 0.001). The most often
detected risk factors were elevated cholesterol (in 44%), arterial hypertension (in 40%),
obesity (in 32%), and smoking (in 24%). Most of the children (64%) had only one additional
risk factor, while in the remaining 36% the most prevalent risk factors were overweight
(in 14 out of 18) and arterial hypertension (in 11 out of 18). It is concluded that
cardiovascular risk factor screening among children with a positive family history of
premature atherosclerotic complications is appropriate and cost-effective.
Ključne riječi
cardiovascular diseases; epidemiology; risk factors; myocardial infarction; offspring
Hrčak ID:
28099
URI
Datum izdavanja:
16.6.2003.
Posjeta: 797 *