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Complex Segregation Analysis of Body Height, Weight and BMI in Pedigree Data from Middle Dalmatia, Croatia

Tatjana Škarić-Jurić
Emil Ginsburg
Eugene Kobyliansky
Ida Malkin
Nina Smolej Narančić
Pavao Rudan


Puni tekst: engleski pdf 173 Kb

str. 135-149

preuzimanja: 642

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Sažetak

It has recently been reported that the mode of inheritance of body height, weight and
BMI in five ethnically and geographically different populations can be described in
terms of a major gene (MG) model1. Here, using the pedigree sample from the island
populations of Middle Dalmatia, Croatia (1,312 observed individuals in 462 pedigrees),
the evidence is presented that supports the above findings. By applying the usual transmission
probability tests, the hypothesis has been accepted that a significant part of the
variation of each one of those three basic morphological traits can be attributed to the effect
of a putative large-effect gene. The effect of a putative MG is responsible for 39–50%
of age and sex adjusted trait’s variation and for 34–48% of the total (non age-adjusted)
variation of height, weight and BMI.

Ključne riječi

complex segregation analysis; body height; body weight; BMI; Croatia

Hrčak ID:

28102

URI

https://hrcak.srce.hr/28102

Datum izdavanja:

16.6.2003.

Posjeta: 1.076 *