Izvorni znanstveni članak
Paraoxonase Activity and Concentration of Indicators of Lipids Status in the Serum of Cardiac Patients
Željko Romić
Ljiljana Mayer
Željko Sutlić
Ino Husedžinović
Bojan Biočina
Roberta Petlevski
Irena Žuntar
Tihana Žanić-Grubišić
Dubravka Juretić
Sažetak
In this research, we measured the activity of paraoxonase (basal and activated) enzyme,
and components of lipid status components (total cholesterol, LDL cholesterol,
HDL cholesterol and Apo A I) in the serum of patients, undergoing bypass surgery. We
also tested how the applied EKC affected changes of defined indicators. Measuring of
all the given parameters was conducted prior to the operation, 90 minutes, 1.5 hour, 6
hours, 24 hours and 72 hours, on 29 patients (11 of them did undergo myocardium
revascularization with the application of EKC, while the rest of them did not). Activity
of paraoxonase (both basal and activated) changes significantly during the postoperative
period, in relation to pre-operative values, p < 0.05. Total cholesterol concentration
is reduced in both examined groups, regardless of the application of EKC. This trend is
also accompanied by LDL cholesterol concentration. On the other hand, HDL cholesterol
concentration during post-operative period does not indicate any significant statistical
change in relation to pre-operative values, while we noticed difference with regard
to EKC application, 90 minutes after surgery. This change of lipid status indicator is
partly due to heparin, a stimulator of lipoprotein lipase that was applied during the
surgery. Our conclusion is that lipid profile changes significantly after the bypass surgery,
mostly regardless of the application of EKC.
Ključne riječi
paraoxonase activity; lipids status; cardiac patients
Hrčak ID:
28128
URI
Datum izdavanja:
26.6.2003.
Posjeta: 904 *