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Drug Delivery by TAT-technology

Mira Grdiša   ORCID icon orcid.org/0000-0001-5422-7188 ; Ruđer Bošković Institute, Zagreb, Croatia
Ana-Matea Mikecin ; Ruđer Bošković Institute, Zagreb, Croatia

Puni tekst: engleski, pdf (72 KB) str. 223-226 preuzimanja: 913* citiraj
APA 6th Edition
Grdiša, M. i Mikecin, A. (2008). Drug Delivery by TAT-technology. Croatica Chemica Acta, 81 (2), 223-226. Preuzeto s https://hrcak.srce.hr/28144
MLA 8th Edition
Grdiša, Mira i Ana-Matea Mikecin. "Drug Delivery by TAT-technology." Croatica Chemica Acta, vol. 81, br. 2, 2008, str. 223-226. https://hrcak.srce.hr/28144. Citirano 22.01.2020.
Chicago 17th Edition
Grdiša, Mira i Ana-Matea Mikecin. "Drug Delivery by TAT-technology." Croatica Chemica Acta 81, br. 2 (2008): 223-226. https://hrcak.srce.hr/28144
Harvard
Grdiša, M., i Mikecin, A. (2008). 'Drug Delivery by TAT-technology', Croatica Chemica Acta, 81(2), str. 223-226. Preuzeto s: https://hrcak.srce.hr/28144 (Datum pristupa: 22.01.2020.)
Vancouver
Grdiša M, Mikecin A. Drug Delivery by TAT-technology. Croatica Chemica Acta [Internet]. 2008 [pristupljeno 22.01.2020.];81(2):223-226. Dostupno na: https://hrcak.srce.hr/28144
IEEE
M. Grdiša i A. Mikecin, "Drug Delivery by TAT-technology", Croatica Chemica Acta, vol.81, br. 2, str. 223-226, 2008. [Online]. Dostupno na: https://hrcak.srce.hr/28144. [Citirano: 22.01.2020.]

Sažetak
TAT technology is a biochemical technique for introduction of full-length peptides or proteins into cells. This process occurs in a rapid, concentration-dependent fashion that appears to be independent of receptors and transporters. It has broad implications in experimental systems for regulating intracellular processes and has the potential to be used in the development of new therapeutic strategies for cancer, infectious diseases, and development of vaccines. It has been shown that different forms of TAT-p27 protein can modulate the cell cycle of cultured cell lines, depending on the concentration and type of cells. Transfer of TAT-proteins/peptides use from cell culture systems to animal disease models has been slow, but the ability of TAT conjugates
to protect mice against ischemia, inhibit tumor growth, and enhance gene delivery suggests
that they offer wide ranging pharmaceutical applications for treating a whole range of
diseases.

Ključne riječi
TAT-vector; protein transduction; drug delivery

Hrčak ID: 28144

URI
https://hrcak.srce.hr/28144

Posjeta: 1.172 *