Izvorni znanstveni članak
Phylogeny of Vertebrate Nuclear Receptors – Analysis of Variance Components in Protein Sequences
Inna Gurel
Gregory Livshits
Sažetak
Nuclear receptors (NR) constitute a large family of proteins and play a crucial role in
regulating mineral metabolism and physiological homeostasis of various organ systems.
The aim of this study was to elucidate whether the variance among NRs of estrogen, androgen
and vitamin-D in various vertebrate species including humans is attributed to
differences between the taxonomic groups within a specific receptor (i.e. between orthologous)
or between the different proteins within the taxon (i.e. between paralogous genes).
Published data on 57 protein sequences of the above NRs were used for phylogenetic
analysis. The results showed that in DNA- and ligand-binding regions, 94% and 70% of
variance is due to differences between the three proteins. However, in non-binding regions,
47% of the variance results from differences between the three paralogous proteins.
Human sequences consistently clustered with their mammal orthologous within
the three groups of NR sequences, clearly indicating that evolution of human sequences
is not distinct from mammal sequence evolution.
Ključne riječi
nuclear receptors; protein sequences; phylogeny; vertebrate; analysis of variance
Hrčak ID:
28170
URI
Datum izdavanja:
15.12.2003.
Posjeta: 982 *