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Free Radical Scavenging Activity of Hydroxyflavone Sodium Salts Compared to the Activity of Hydroxyflavones Themselves

Milane A. Hadi
Thierry F. Vandamme
Min-jie Zhao
Marc Kessler
Geneviève Ubeaud
Beatriz Aguilar Ochandio
Louis Jung

Puni tekst: engleski, pdf (90 KB) str. 35-41 preuzimanja: 773* citiraj
APA 6th Edition
Hadi, M.A., Vandamme, T.F., Zhao, M., Kessler, M., Ubeaud, G., Ochandio, B.A. i Jung, L. (2005). Free Radical Scavenging Activity of Hydroxyflavone Sodium Salts Compared to the Activity of Hydroxyflavones Themselves. Croatica Chemica Acta, 78 (1), 35-41. Preuzeto s https://hrcak.srce.hr/2663
MLA 8th Edition
Hadi, Milane A., et al. "Free Radical Scavenging Activity of Hydroxyflavone Sodium Salts Compared to the Activity of Hydroxyflavones Themselves." Croatica Chemica Acta, vol. 78, br. 1, 2005, str. 35-41. https://hrcak.srce.hr/2663. Citirano 08.03.2021.
Chicago 17th Edition
Hadi, Milane A., Thierry F. Vandamme, Min-jie Zhao, Marc Kessler, Geneviève Ubeaud, Beatriz Aguilar Ochandio i Louis Jung. "Free Radical Scavenging Activity of Hydroxyflavone Sodium Salts Compared to the Activity of Hydroxyflavones Themselves." Croatica Chemica Acta 78, br. 1 (2005): 35-41. https://hrcak.srce.hr/2663
Harvard
Hadi, M.A., et al. (2005). 'Free Radical Scavenging Activity of Hydroxyflavone Sodium Salts Compared to the Activity of Hydroxyflavones Themselves', Croatica Chemica Acta, 78(1), str. 35-41. Preuzeto s: https://hrcak.srce.hr/2663 (Datum pristupa: 08.03.2021.)
Vancouver
Hadi MA, Vandamme TF, Zhao M, Kessler M, Ubeaud G, Ochandio BA i sur. Free Radical Scavenging Activity of Hydroxyflavone Sodium Salts Compared to the Activity of Hydroxyflavones Themselves. Croatica Chemica Acta [Internet]. 2005 [pristupljeno 08.03.2021.];78(1):35-41. Dostupno na: https://hrcak.srce.hr/2663
IEEE
M.A. Hadi, et al., "Free Radical Scavenging Activity of Hydroxyflavone Sodium Salts Compared to the Activity of Hydroxyflavones Themselves", Croatica Chemica Acta, vol.78, br. 1, str. 35-41, 2005. [Online]. Dostupno na: https://hrcak.srce.hr/2663. [Citirano: 08.03.2021.]

Sažetak
Different studies have demonstrated that the bioactivity of hydroxyflavones is due to their antioxidant and free radical scavenging activity. Recently, most interest has been devoted to structure- activity relationships; however, the main problems encountered in these studies are the low solubility of some hydroxyflavones in aqueous solution and the pro-oxidant character of the hydroxyl group at the 3 position. In the present investigation, these problems have been resolved by preparing the corresponding hydroxyflavone sodium salts. In this way, the hydroxyl free radical (OH)• scavenging activity of different hydroxyflavone salts were studied using the Fenton reaction model, and the superoxide (O2)• – scavenging activity was studied using the xanthine oxidase model. The results obtained show clearly that the (OH)• scavenging activity of the hydroxyflavone salt form is at least two times that of the corresponding hydroxyflavone itself. Considering the (O2)• – scavenging activity, the salt form of hydroxyflavone is as good as the corresponding hydroxyflavone. Moreover, it was observed that for a good scavenging activity the hydroxyl at the 3' position must be free, and only the hydroxyl groups of 3 and 4' have to be substituted by sodium when the sodium salt of hydroxyflavone at position 7 does not have an important role in radical scavenging. The salt forms of hydroxyflavones are interesting free radical scavenger compounds showing a hydrophilic character.

Ključne riječi
free radical; scavenging activity; quercetin; hydroxyflavones; salts; pro-oxidant; antioxidant

Hrčak ID: 2663

URI
https://hrcak.srce.hr/2663

[hrvatski]

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