Recenzija, Prikaz slučaja
Review on Prostaglandin and Oxytocin Activity in Preterm Labor
M. Ivanišević
J. Djelmiš
D. Buković
Sažetak
The principal difference between term and preterm labor is how they are activated. It
has been proposed that term labor results from physiological activation of the common
terminal pathway, whereas preterm labor is a pathological condition caused by multiple
etiologies that activate one or more of the components of this pathway. Increased
uterine contractility at preterm labor results from activation and stimulation of the
myometrium. Myometrium is stimulated by increased concentrations of prostaglandins
and oxytocin. Increased production of stimulatory prostaglandins by intrauterine tissues
is generally considered a central component of the cascade of events leading to
preterm parturition. Prostaglandins act to mediate cervical ripening and to stimulate
uterine contractions and indirectly to increase fundally dominant myometrial contractility
by up regulation of gap junctions, oxytocin and arginine vasopressin receptors and
synchronizations of contractions. The authors tried to explain the role and influence of
oxytocin in human parturition, as well as the novel therapy in inhibiting the contractions
in preterm labor. The selective oxytocin inhibitor was tested in vitro on human
myometrium and decidua by the author of this article among the first in the world.
Ključne riječi
Hrčak ID:
28462
URI
Datum izdavanja:
17.12.2001.
Posjeta: 2.210 *