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Acta Pharmaceutica, Vol. 58 No. 4, 2008.

Kratko priopćenje
https://doi.org/10.2478/v10007-008-0028-x

Sinteza i biološko vrednovanje 4-(1H-indol-3-il)-6-fenil 1,2,3,4-tetrahidropirimidin-2-ona/tiona kao jakih protuuplanih tvari

MOHAMMAD AMIR ; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University (Jamia Hamdard), New Delhi-10062, India
SADIQUE AKHTAR JAVED ; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University (Jamia Hamdard), New Delhi-10062, India
HARISH KUMAR ; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University (Jamia Hamdard), New Delhi-10062, India

Puni tekst: engleski, pdf (91 KB) str. 467-477 preuzimanja: 626* citiraj
APA 6th Edition
AMIR, M., JAVED, S.A. i KUMAR, H. (2008). Synthesis and biological evaluation of some 4-(1H-indol-3-yl)-6-phenyl 1,2,3,4-tetrahydropyrimidin-2-ones/thiones as potent anti-inflammatory agents. Acta Pharmaceutica, 58 (4), 467-477. https://doi.org/10.2478/v10007-008-0028-x
MLA 8th Edition
AMIR, MOHAMMAD, et al. "Synthesis and biological evaluation of some 4-(1H-indol-3-yl)-6-phenyl 1,2,3,4-tetrahydropyrimidin-2-ones/thiones as potent anti-inflammatory agents." Acta Pharmaceutica, vol. 58, br. 4, 2008, str. 467-477. https://doi.org/10.2478/v10007-008-0028-x. Citirano 23.02.2019.
Chicago 17th Edition
AMIR, MOHAMMAD, SADIQUE AKHTAR JAVED i HARISH KUMAR. "Synthesis and biological evaluation of some 4-(1H-indol-3-yl)-6-phenyl 1,2,3,4-tetrahydropyrimidin-2-ones/thiones as potent anti-inflammatory agents." Acta Pharmaceutica 58, br. 4 (2008): 467-477. https://doi.org/10.2478/v10007-008-0028-x
Harvard
AMIR, M., JAVED, S.A., i KUMAR, H. (2008). 'Synthesis and biological evaluation of some 4-(1H-indol-3-yl)-6-phenyl 1,2,3,4-tetrahydropyrimidin-2-ones/thiones as potent anti-inflammatory agents', Acta Pharmaceutica, 58(4), str. 467-477. doi: https://doi.org/10.2478/v10007-008-0028-x
Vancouver
AMIR M, JAVED SA, KUMAR H. Synthesis and biological evaluation of some 4-(1H-indol-3-yl)-6-phenyl 1,2,3,4-tetrahydropyrimidin-2-ones/thiones as potent anti-inflammatory agents. Acta Pharm. [Internet]. 2008 [pristupljeno 23.02.2019.];58(4):467-477. doi: https://doi.org/10.2478/v10007-008-0028-x
IEEE
M. AMIR, S.A. JAVED i H. KUMAR, "Synthesis and biological evaluation of some 4-(1H-indol-3-yl)-6-phenyl 1,2,3,4-tetrahydropyrimidin-2-ones/thiones as potent anti-inflammatory agents", Acta Pharmaceutica, vol.58, br. 4, str. 467-477, 2008. [Online]. doi: https://doi.org/10.2478/v10007-008-0028-x

Sažetak
Dvanaest novih 4-(1H-indol-3-il)-6-fenil-1,2,3,4-tetrahidropirimidin-2-ona/tiona (7-18) sintetizirano je reakcijom 1-aril-3-(1H-indol-3-il)-2-propen-1-ona s ureom i tioureom u etanolnoj otopini kalijeva hidroksida. Njihove strukture potvrđene su IR, 1H NMR i masenom spektrometrijom. Farmakološko vrednovanje pokazalo je da ti spojevi imaju od 49,5 do 70,7% protuupalnog djelovanja, dok je standardni lijek ibuprofen pokazao 86,4% djelovanja uz istu peroralno uzetu dozu. Spojevi koji pokazuju značajno protuupalno djelovanje (8, 10, 14, 16) ispitani su na ulcerogenost i djelovanje na lipidnu peroksidaciju. Svi testirani spojevi su značajno manje ulcerogeni i manje djeluju na lipidnu peroksidaciju od ibuprofena.

Ključne riječi
derivati pirimidina; protuupalno djelovanje; ulcerogenost; lipidna peroksidacija

Hrčak ID: 28799

URI
https://hrcak.srce.hr/28799

[engleski]

Posjeta: 904 *