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In Vitro and In Vivo Micronucleus Tests in Genotoxicological Research

Aleksandra Fučić
August Mijić

Puni tekst: hrvatski, pdf (95 KB) str. 299-306 preuzimanja: 2.132* citiraj
APA 6th Edition
Fučić, A. i Mijić, A. (1999). In vitro i in vivo mikronukleus metode u genotoksikološkim istraživanjima. Arhiv za higijenu rada i toksikologiju, 50 (3), 299-306. Preuzeto s https://hrcak.srce.hr/2720
MLA 8th Edition
Fučić, Aleksandra i August Mijić. "In vitro i in vivo mikronukleus metode u genotoksikološkim istraživanjima." Arhiv za higijenu rada i toksikologiju, vol. 50, br. 3, 1999, str. 299-306. https://hrcak.srce.hr/2720. Citirano 01.10.2020.
Chicago 17th Edition
Fučić, Aleksandra i August Mijić. "In vitro i in vivo mikronukleus metode u genotoksikološkim istraživanjima." Arhiv za higijenu rada i toksikologiju 50, br. 3 (1999): 299-306. https://hrcak.srce.hr/2720
Harvard
Fučić, A., i Mijić, A. (1999). 'In vitro i in vivo mikronukleus metode u genotoksikološkim istraživanjima', Arhiv za higijenu rada i toksikologiju, 50(3), str. 299-306. Preuzeto s: https://hrcak.srce.hr/2720 (Datum pristupa: 01.10.2020.)
Vancouver
Fučić A, Mijić A. In vitro i in vivo mikronukleus metode u genotoksikološkim istraživanjima. Arh Hig Rada Toksikol. [Internet]. 1999 [pristupljeno 01.10.2020.];50(3):299-306. Dostupno na: https://hrcak.srce.hr/2720
IEEE
A. Fučić i A. Mijić, "In vitro i in vivo mikronukleus metode u genotoksikološkim istraživanjima", Arhiv za higijenu rada i toksikologiju, vol.50, br. 3, str. 299-306, 1999. [Online]. Dostupno na: https://hrcak.srce.hr/2720. [Citirano: 01.10.2020.]

Sažetak
Working and living environment today is an unpredictable mixture of different chemical substances. Some of these chemicals are mutagenic carcinogens and others are aneugenic carcinogens. An additional burden to the human genome is the exposure to several kinds of radiations. Among a dozen genotoxicological methods in use in vitro and in vivo, the micronucleus assay has found application in the basic research, clinical reasearch, and pharmacological studies. The advantage of in vivo and in vitro micronucleus assays is in the fact that they provide data on both clastogenic and aneugenic action of agents. Although several years behind the in vitro technique, the in vivo micronucleus assay has swiftly developed into a significant source of data in acute and chronic genotoxic investigations, as it does not require cell culture.

Ključne riječi
aneugenic carcinogens; cytogenetic methods; genotoxicological research; micronucleus tests; mutagenic carcinogens

Hrčak ID: 2720

URI
https://hrcak.srce.hr/2720

[hrvatski]

Posjeta: 2.766 *