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Acta Pharmaceutica, Vol. 58 No. 4, 2008.

Izvorni znanstveni članak
https://doi.org/10.2478/v10007-008-0030-3

The reaction of β-amino-α,γ-dicyanocrotononitrile with acetophenone: synthesis of pyridine, pyridazine and thiophene derivatives with antimicrobial activities

RAFAT M. MOHAREB ; Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt
KARAM A. El-SHARKAWY ; Department of Organic Chemistry, Faculty of Pharmacy, October University for Modern Sciences and Arts (MSA), October, A. R. Egypt
SHERIF M. SHERIF ; Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt

Puni tekst: engleski, pdf (110 KB) str. 429-444 preuzimanja: 880* citiraj
APA 6th Edition
MOHAREB, R.M., El-SHARKAWY, K.A. i SHERIF, S.M. (2008). The reaction of β-amino-α,γ-dicyanocrotononitrile with acetophenone: synthesis of pyridine, pyridazine and thiophene derivatives with antimicrobial activities. Acta Pharmaceutica, 58 (4), 429-444. https://doi.org/10.2478/v10007-008-0030-3
MLA 8th Edition
MOHAREB, RAFAT M., et al. "The reaction of β-amino-α,γ-dicyanocrotononitrile with acetophenone: synthesis of pyridine, pyridazine and thiophene derivatives with antimicrobial activities." Acta Pharmaceutica, vol. 58, br. 4, 2008, str. 429-444. https://doi.org/10.2478/v10007-008-0030-3. Citirano 21.02.2019.
Chicago 17th Edition
MOHAREB, RAFAT M., KARAM A. El-SHARKAWY i SHERIF M. SHERIF. "The reaction of β-amino-α,γ-dicyanocrotononitrile with acetophenone: synthesis of pyridine, pyridazine and thiophene derivatives with antimicrobial activities." Acta Pharmaceutica 58, br. 4 (2008): 429-444. https://doi.org/10.2478/v10007-008-0030-3
Harvard
MOHAREB, R.M., El-SHARKAWY, K.A., i SHERIF, S.M. (2008). 'The reaction of β-amino-α,γ-dicyanocrotononitrile with acetophenone: synthesis of pyridine, pyridazine and thiophene derivatives with antimicrobial activities', Acta Pharmaceutica, 58(4), str. 429-444. doi: https://doi.org/10.2478/v10007-008-0030-3
Vancouver
MOHAREB RM, El-SHARKAWY KA, SHERIF SM. The reaction of β-amino-α,γ-dicyanocrotononitrile with acetophenone: synthesis of pyridine, pyridazine and thiophene derivatives with antimicrobial activities. Acta Pharm. [Internet]. 2008 [pristupljeno 21.02.2019.];58(4):429-444. doi: https://doi.org/10.2478/v10007-008-0030-3
IEEE
R.M. MOHAREB, K.A. El-SHARKAWY i S.M. SHERIF, "The reaction of β-amino-α,γ-dicyanocrotononitrile with acetophenone: synthesis of pyridine, pyridazine and thiophene derivatives with antimicrobial activities", Acta Pharmaceutica, vol.58, br. 4, str. 429-444, 2008. [Online]. doi: https://doi.org/10.2478/v10007-008-0030-3

Sažetak
Condensation of β-amino-α,γ-dicyanocrotononitrile (1) with acetophenone gave the 2-amino-4-phenylpenta-1,3-diene-1,1,3-tricarbonitrile (2). The latter product was used in a series of heterocyclization reactions when react with different reagents like diazonium salts, hydrazines, hydroxylamine and elemental sulfur to give pyridazine, pyrazole, isoxazole and thiophene derivatives, respectively. On the other hand, it gave pyridine derivatives with aromatic aldehydes followed by reaction with cyanomethylene reagents. The MIC values for the newly synthesized product were measured against E. coli, B. cereus, B. subtilis and C. albicans

Ključne riječi
pyridine; isoxazole; pyridazine; thiophene; antimicrobial activity

Hrčak ID: 28934

URI
https://hrcak.srce.hr/28934

[hrvatski]

Posjeta: 1.194 *