Pregledni rad

Identical and Nonidentical Twin Drugs

M. Huzjak ; Farmaceutsko-biokemijski fakultet Sveučilišta u Zagrebu, Zagreb, Hrvatska
Z. Rajić ; Farmaceutsko-biokemijski fakultet Sveučilišta u Zagrebu, Zagreb, Hrvatska
B. Zorc ; Farmaceutsko-biokemijski fakultet Sveučilišta u Zagrebu, Zagreb, Hrvatska

Sažetak

Twin drugs contain two pharmacophoric groups combined covalently in a single molecule. Pharmacophoric groups can be identical moieties (identical twin drugs) or different (nonidentical twin drugs). Identical twin drugs can act on receptors (biogenic amine receptors, peptide receptors, Ca2+ channel, σ receptors in the brain, leukotriene B₄ receptors), as enzyme inhibitors (HIVenzyme, protein kinase, prolyl hydrolase, acyl-CoA cholesterol acyl transferase, spermidine- spermine-N1-acetyltransferase, S-adenosylmethionine decarboxylase), and as DNA ligands. Nonidentical twin drugs exert their dual action on two different receptors, on two binding sites of a single receptor, on two enzymes, or on both a receptor and an enzyme.

Ključne riječi

twin drugs; receptors; enzymes

Hrčak ID:

29417

URI

https://hrcak.srce.hr/29417

Datum izdavanja:

5.11.2008.

Podaci na drugim jezicima: hrvatski

Posjeta: 1.869 *