Medica Jadertina, Vol. 38 No. 3-4, 2008.
Stručni rad
Predictive power of Ki-67 antigen expression in patients with uveal melanomas
Ana Krvavica
; Opća bolnica Zadar, Odjel patologije i sudske medicine
Sažetak
The aim of this short study was to investigate the expression of Ki-67 immunocomplex in uveal melanoma cells, to examine if the expression intensity corellates with the morphologic cell type, to establish if the expression intensity corellates with the invasion levels which would result in prognostic significance.
30 uveal melanomas were examined in order to test the presence of Ki-67 protein by indirect peroxidaseantiperoxidase method and monoclonal antibody for Ki-67 protein. The intensity of the reaction was marked negative, weakly positive, moderately positive or strongly positive by the semiquantitative method. The immunoreaction was found to be negative in 3 spindle cell melanomas and 1 epitheloid; weakly positive in 3 spindle cell melanomas, moderately positive in 6 spindle cell melanoma, 6 of mixed cellularity and 3 of epitheloid type. The intensity was strongest in 1 spindle cell, 6 tumors of mixed cellularity and one epitheloid. In our samples from the pT2 stage most tumors were moderately positive (30%), and a minor number of cases were weakly positive (6,6%), but in the pT3 stage 26,7% of tumors showed the strongest
intensity of reaction.
Ključne riječi
Ki-67 oncogen; melanocyte proliferation; uveal melanoma; tumor markers
Hrčak ID:
29484
URI
Datum izdavanja:
1.12.2008.
Posjeta: 4.441 *