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Arhiv za higijenu rada i toksikologiju, Vol.59 No.4 Prosinac 2008.

Izvorni znanstveni članak
https://doi.org/10.2478/10004-1254-59-2008-1924

The Association of OGG1 Ser326Cys Polymorphism and Urinary 8-OHdG Levels With Lung Cancer Susceptibility: A Hospital-Based Case-Control Study in Turkey

Bensu Karahalil ; Gazi University, Faculty of Pharmacy, Department of Toxicology, Ankara, Turkey
Esra Emerce ; Gazi University, Faculty of Pharmacy, Department of Toxicology, Ankara, Turkey
Bülent Kocer ; Ankara Numune Education and Research, Ankara, Turkey
Serdar Han ; Ankara Numune Education and Research, Ankara, Turkey
Necati Alkis ; Ankara Oncology Education and Research Hospital, Department ofMedical Oncology, Ankara, Turkey
Ali Esat Karakaya ; Gazi University, Faculty of Pharmacy, Department of Toxicology, Ankara, Turkey

Puni tekst: engleski, pdf (100 KB) str. 241-250 preuzimanja: 518* citiraj
APA 6th Edition
Karahalil, B., Emerce, E., Kocer, B., Han, S., Alkis, N. i Karakaya, A.E. (2008). The Association of OGG1 Ser326Cys Polymorphism and Urinary 8-OHdG Levels With Lung Cancer Susceptibility: A Hospital-Based Case-Control Study in Turkey. Arhiv za higijenu rada i toksikologiju, 59 (4), 241-250. https://doi.org/10.2478/10004-1254-59-2008-1924
MLA 8th Edition
Karahalil, Bensu, et al. "The Association of OGG1 Ser326Cys Polymorphism and Urinary 8-OHdG Levels With Lung Cancer Susceptibility: A Hospital-Based Case-Control Study in Turkey." Arhiv za higijenu rada i toksikologiju, vol. 59, br. 4, 2008, str. 241-250. https://doi.org/10.2478/10004-1254-59-2008-1924. Citirano 23.10.2018.
Chicago 17th Edition
Karahalil, Bensu, Esra Emerce, Bülent Kocer, Serdar Han, Necati Alkis i Ali Esat Karakaya. "The Association of OGG1 Ser326Cys Polymorphism and Urinary 8-OHdG Levels With Lung Cancer Susceptibility: A Hospital-Based Case-Control Study in Turkey." Arhiv za higijenu rada i toksikologiju 59, br. 4 (2008): 241-250. https://doi.org/10.2478/10004-1254-59-2008-1924
Harvard
Karahalil, B., et al. (2008). 'The Association of OGG1 Ser326Cys Polymorphism and Urinary 8-OHdG Levels With Lung Cancer Susceptibility: A Hospital-Based Case-Control Study in Turkey', Arhiv za higijenu rada i toksikologiju, 59(4), str. 241-250. doi: https://doi.org/10.2478/10004-1254-59-2008-1924
Vancouver
Karahalil B, Emerce E, Kocer B, Han S, Alkis N, Karakaya AE. The Association of OGG1 Ser326Cys Polymorphism and Urinary 8-OHdG Levels With Lung Cancer Susceptibility: A Hospital-Based Case-Control Study in Turkey. Arh Hig Rada Toksikol. [Internet]. 08.12.2008. [pristupljeno 23.10.2018.];59(4):241-250. doi: https://doi.org/10.2478/10004-1254-59-2008-1924
IEEE
B. Karahalil, E. Emerce, B. Kocer, S. Han, N. Alkis i A.E. Karakaya, "The Association of OGG1 Ser326Cys Polymorphism and Urinary 8-OHdG Levels With Lung Cancer Susceptibility: A Hospital-Based Case-Control Study in Turkey", Arhiv za higijenu rada i toksikologiju, vol.59, br. 4, str. 241-250, prosinac 2008. [Online]. doi: https://doi.org/10.2478/10004-1254-59-2008-1924

Sažetak
High incidence and poor prognosis of lung cancer make it a major health problem worldwide. Although smoking is a major cause of lung cancer, only some smokers develop lung cancer, which suggests that there is a genetic predisposition in some individuals. 8-OHG is an important oxidative base lesion and may elevate due to cancer and smoking. It is repaired by 8-hydroxyguanine DNA glycosylase 1 (OGG1), which has several polymorphisms. Although the Ser326Cys polymorphism is consistently associated with a range of cancers, findings about this polymorphism and lung cancer risk are contradictory. To date, no study has examined this association in the Turkish population. We conducted a case-control study to investigate the association between OGG1 Ser326Cys polymorphism and the risk of lung cancer using PCR-RFLP. We also evaluated gene-smoking interaction and excretion of urinary 8-OHdG. Our results suggest that the OGG1 Ser326Cys polymorphism is not a genetic risk factor for lung cancer, and that the heterozygous genotype is associated with a significantly reduced risk for lung cancer. The levels of 8-OHdG did not correlate with the polymorphism and smoking. Larger association studies are needed to validate our findings, and mechanistic studies are needed to elucidate the underlying molecular mechanisms of this association.

Ključne riječi
disease; ELISA; genetic variation; oxidative stress; pharmacogenomic; RFLP

Hrčak ID: 29556

URI
https://hrcak.srce.hr/29556

[hrvatski]

Posjeta: 960 *