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Arhiv za higijenu rada i toksikologiju, Vol.59 No.4 Prosinac 2008.

Stručni rad
https://doi.org/10.2478/10004-1254-59-2008-1884

Life-threatening Valproate Overdose Successfully Treated with Haemodialysis

Julije Meštrović ; Department of Paediatrics, Paediatric Intensive Care Unit, University Hospital Split, Split, Croatia
Tomislav Filipović ; Department of Internal Medicine, Division of Nephrology, University Hospital Split, Split, Croatia
Branka Polić ; Department of Paediatrics, Paediatric Intensive Care Unit, University Hospital Split, Split, Croatia
Luka Stričević ; Department of Paediatrics, Paediatric Intensive Care Unit, University Hospital Split, Split, Croatia
Ante Omazić ; Department of Paediatrics, Paediatric Intensive Care Unit, University Hospital Split, Split, Croatia
Radenka Kuzmanić-Šamija ; Department of Paediatrics, Division of Neurology, University Hospital Split, Split, Croatia
Joško Markić ; Department of Paediatrics, Paediatric Intensive Care Unit, University Hospital Split, Split, Croatia

Puni tekst: engleski, pdf (57 KB) str. 295-298 preuzimanja: 1.252* citiraj
APA 6th Edition
Meštrović, J., Filipović, T., Polić, B., Stričević, L., Omazić, A., Kuzmanić-Šamija, R. i Markić, J. (2008). Life-threatening Valproate Overdose Successfully Treated with Haemodialysis. Arhiv za higijenu rada i toksikologiju, 59 (4), 295-298. https://doi.org/10.2478/10004-1254-59-2008-1884
MLA 8th Edition
Meštrović, Julije, et al. "Life-threatening Valproate Overdose Successfully Treated with Haemodialysis." Arhiv za higijenu rada i toksikologiju, vol. 59, br. 4, 2008, str. 295-298. https://doi.org/10.2478/10004-1254-59-2008-1884. Citirano 17.10.2018.
Chicago 17th Edition
Meštrović, Julije, Tomislav Filipović, Branka Polić, Luka Stričević, Ante Omazić, Radenka Kuzmanić-Šamija i Joško Markić. "Life-threatening Valproate Overdose Successfully Treated with Haemodialysis." Arhiv za higijenu rada i toksikologiju 59, br. 4 (2008): 295-298. https://doi.org/10.2478/10004-1254-59-2008-1884
Harvard
Meštrović, J., et al. (2008). 'Life-threatening Valproate Overdose Successfully Treated with Haemodialysis', Arhiv za higijenu rada i toksikologiju, 59(4), str. 295-298. doi: https://doi.org/10.2478/10004-1254-59-2008-1884
Vancouver
Meštrović J, Filipović T, Polić B, Stričević L, Omazić A, Kuzmanić-Šamija R i sur. Life-threatening Valproate Overdose Successfully Treated with Haemodialysis. Arh Hig Rada Toksikol. [Internet]. 08.12.2008. [pristupljeno 17.10.2018.];59(4):295-298. doi: https://doi.org/10.2478/10004-1254-59-2008-1884
IEEE
J. Meštrović, et al., "Life-threatening Valproate Overdose Successfully Treated with Haemodialysis", Arhiv za higijenu rada i toksikologiju, vol.59, br. 4, str. 295-298, prosinac 2008. [Online]. doi: https://doi.org/10.2478/10004-1254-59-2008-1884

Sažetak
Valproate (VPA) poisoning is an increasing clinical problem. The most common finding in VPA overdose is the depression of the central nervous system, which may progress to coma and death. This type of poisoning is difficult to treat, as no antidote exists. This report describes a case with a 16-year-old girl who poisoned herself with valproate. Initial treatment included naloxone, but she did not respond. She became comatose, with serum VPA concentration of 1320 µg mL-1. Three sessions of haemodialysis were performed, effectively eliminating VPA and decreasing the serum concentration. The patient regained consciousness and fully recovered. To our knowledge, this is the highest serum VPA concentration reported by now in children aged 16 or less. Haemodialysis has proved to be the treatment of choice for life-threatening acute VPA overdose in children.

Ključne riječi
central nervous system depressants; intensive care; thrombocytopenia; toxicity

Hrčak ID: 29563

URI
https://hrcak.srce.hr/29563

[hrvatski]

Posjeta: 1.718 *