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Investigation of Genomic Instability in Patients with Sjögren’s Syndrome by Using Sister Chromatid Exchange Analysis
Sertan Ergun
; Zavod za oralnu medicinu i kirurgiju Stomatološkog fakulteta Sveučilišta u Istambulu, Istambul, Turska
Hakki Tanyeri
; Zavod za oralnu medicinu i kirurgiju Stomatološkog fakulteta Sveučilišta u Istambulu, Istambul, Turska
Şükrü Öztürk
; Zavod za internu medicinu - Odjel za medicinsku genetiku Medicinskog fakulteta Sveučilišta u Istambulu, Istambul, Turska
Nilgün Duman
; Institut za zdravstvenu znanost - Zavod za genetiku Sveučilišta u Istambulu, Istambul, Turska
Sevil Kamal
; Zavod za internu medicinu - Odjel za reumatologiju Medicinskog fakulteta Sveučilišta u Istambulu, Istambul, Turska
Ahmet Gül
; Zavod za internu medicinu - Odjel za reumatologiju Medicinskog fakulteta Sveučilišta u Istambulu, Istambul, Turska
Reyhan Küçükkaya
; Zavod za internu medicinu - Odjel za hematologiju Medicinskog fakulteta Istambulskog sveučilišta, Istambul, Turska
Sevda Özel
; Zavod za javno zdravstvo - Medicinski fakultet Istambulskog sveučilišta, Istambul, Turska
Kivanç Çefle
; Zavod za internu medicinu - Odjel za medicinsku genetiku Medicinskog fakulteta Sveučilišta u Istambulu, Istambul, Turska
Sükrü Palanduz
; Zavod za internu medicinu - Odjel za medicinsku genetiku Medicinskog fakulteta Sveučilišta u Istambulu, Istambul, Turska
Sažetak
Purpose: To investigate genomic instability by using Sister Chromatid Exchange (SCE) in the peripheral blood lymphocytes in patients with Sjögren’s syndrome (SS). Patients and Methods: The frequency of SCE (per metaphase) was investigated in patients with primary Sjögren’s Syndrome (n=30), in untreated lymphoma patients (n=15) and healthy individuals (n=15) who constitute the control groups. Results: We found the mean frequencies of SCE in the patients with SS, untreated lymphoma and healthy controls as 7.77±1.50, 8.80±0.75, 6.65±1.50, respectively. We found statistically significant differences between patients with SS and lymphoma (p=0.007) and also between patients with lymphoma and healthy controls (p=0.0001). No significant difference was observed between patients with SS and healthy controls in regard of mean frequencies of SCE (per metaphase). Conclusion: It is well known that up to 5.0% of all SS patients may develop lymphoma. High frequency of SCE is regarded as a cytogenetic biomarker of early mutagenic effect suggesting increased risk of cancer. We observed that the mean frequencies of sister chromatid exchanges (per metaphase) of three patients with SS were higher than those of untreated lymphoma patients. This result can only be verified by prolonged follow-up of these patients. We suggest that results should be interpreted by evaluating other parameters which play important roles in malignant transformation.
Ključne riječi
Sjögren’s syndrome; sister chromatid exchange; lymphoma
Hrčak ID:
30519
URI
Datum izdavanja:
11.12.2008.
Posjeta: 2.233 *