Croatica Chemica Acta, Vol. 81 No. 3, 2008.
Izvorni znanstveni članak
A Fast Stripping Continuous Cyclic Voltammetry Method for Determination of Ultra Trace Amounts of Nalidixic Acid
Parviz Norouzi
Mohammad Reza Ganjali
Bagher Larijani
Sanaz Karamdoust
Sažetak
In recent years, modern electroanalytical techniques, especially cyclic voltammetry, are becoming
increasingly important in the determination of pharmaceutical products. This study presents
a novel method for the determination of nalidixic acid (NA) in flow-injection systems,
called fast stripping continuous cyclic voltammetry. This technique is simple, precise, accurate
and time saving compared to similar methods. Initially, the effects of several method parameters
on sensitivity were tested. Thus, the potential waveform was applied to an Au disk microelectrode
in a continuous way. After a series of experiments, it was concluded that the best
performance was achieved with the basic parameters set at pH = 2, sweep rate of 60 V s–1, accumulation
potential 100 mV and accumulation time 0.7 s. The detection limit was 0.07 pg
mL–1 and the relative standard deviation was 2.2 % at the concentration of 10 nmol dm–3 for 10
runs. Major advantages of this method are (i) it is no longer necessary to remove oxygen from
the test solution, (ii) fast determination of similar compounds by several chromatographic methods
is possible, and (iii) the achieved detection limit is low.
Ključne riječi
nalidixic acid; continuous cyclic voltammetry; fast Fourier transformation; flowing injection
Hrčak ID:
31126
URI
Datum izdavanja:
15.11.2008.
Posjeta: 1.913 *