Izvorni znanstveni članak

Influence of age and gender variations on glomerular filtration rate estimated by the MCQE formula

Giuseppe Lippi ; Institute of Clinical Chemistry, Department of Morphological and Biomedical Science; University of Verona, Verona, Italy
Nicola Tessitore ; Nephrology Section, University of Verona, Verona, Italy
Martina Montagnana ; Institute of Clinical Chemistry, Department of Morphological and Biomedical Science; University of Verona, Verona, Italy
Valeria Bedogna ; Nephrology Section, University of Verona, Verona, Italy
Gian L. Salvagno ; Institute of Clinical Chemistry, Department of Morphological and Biomedical Science; University of Verona, Verona, Italy
Giovanni Targher ; Institute of Endocrinology and Metabolic Diseases, Department of Biomedical and Surgical Sciences, University of Verona, Verona, Italy
Antonio Lupo ; Nephrology Section, University of Verona, Verona, Italy
Gian C. Guidi ; Institute of Clinical Chemistry, Department of Morphological and Biomedical Science; University of Verona, Verona, Italy

Sažetak

Background: In clinical practice, the glomerular filtration rate (GFR) is routinely estimated by the creatinine-based equation developed and validated from the Modification of Diet in Renal Disease (MDRD) Study. However, since this formula estimates the rate of decline in GFR, the Mayo Clinic Quadratic Equation (MCQE) has been developed.
Petients and methods: The purpose of this study was to assess the influence of age and gender variations on GFR estimated by this new equation. Results of 16,631 serum creatinine tests performed in consecutive outpatients were retrieved from the database of our Laboratory Information System. GFR was estimated by both the MDRD and MCQE formulas.
Results: The difference in the estimated GFR between males and females was significantly different when calculated with either MDRD or MCQE formula. Significant gender differences were observed in all age decades by MCQE and in subjects aged >51 years by MDRD. A significant difference in the mean GFR values estimated by either formula was also observed between different age decades in both genders.
Conclusions: The results of this epidemiological analysis indicated the MCQE formula also fail to compensate for age and gender variations.

Ključne riječi

creatinine; glomerular filtration rate; kidney function; MDRD; MCQE

Hrčak ID:

32265

URI

https://hrcak.srce.hr/32265

Datum izdavanja:

5.2.2009.

Podaci na drugim jezicima: hrvatski

Posjeta: 1.549 *