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Acta Pharmaceutica, Vol. 59 No. 2, 2009.

Izvorni znanstveni članak
https://doi.org/10.2478/v10007-009-0011-1

Sinteza i djelovanje novih derivata 1,3,4-oksadiazola

ASIF HUSAIN ; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New Delhi-110062, India
MOHAMMED AJMAL ; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New Delhi-110062, India

Puni tekst: engleski, pdf (84 KB) str. 223-233 preuzimanja: 4.607* citiraj
APA 6th Edition
HUSAIN, A. i AJMAL, M. (2009). Synthesis of novel 1,3,4-oxadiazole derivatives and their biological properties. Acta Pharmaceutica, 59 (2), 223-233. https://doi.org/10.2478/v10007-009-0011-1
MLA 8th Edition
HUSAIN, ASIF i MOHAMMED AJMAL. "Synthesis of novel 1,3,4-oxadiazole derivatives and their biological properties." Acta Pharmaceutica, vol. 59, br. 2, 2009, str. 223-233. https://doi.org/10.2478/v10007-009-0011-1. Citirano 18.02.2019.
Chicago 17th Edition
HUSAIN, ASIF i MOHAMMED AJMAL. "Synthesis of novel 1,3,4-oxadiazole derivatives and their biological properties." Acta Pharmaceutica 59, br. 2 (2009): 223-233. https://doi.org/10.2478/v10007-009-0011-1
Harvard
HUSAIN, A., i AJMAL, M. (2009). 'Synthesis of novel 1,3,4-oxadiazole derivatives and their biological properties', Acta Pharmaceutica, 59(2), str. 223-233. doi: https://doi.org/10.2478/v10007-009-0011-1
Vancouver
HUSAIN A, AJMAL M. Synthesis of novel 1,3,4-oxadiazole derivatives and their biological properties. Acta Pharm. [Internet]. 2009 [pristupljeno 18.02.2019.];59(2):223-233. doi: https://doi.org/10.2478/v10007-009-0011-1
IEEE
A. HUSAIN i M. AJMAL, "Synthesis of novel 1,3,4-oxadiazole derivatives and their biological properties", Acta Pharmaceutica, vol.59, br. 2, str. 223-233, 2009. [Online]. doi: https://doi.org/10.2478/v10007-009-0011-1

Sažetak
Reakcijom 3-(4-brombenzoil)propionske kiseline (3) i aril hidrazida (2a-n) u prisutnosti fosforovog oksiklorida, sintetizirana je serija novih derivata 2-[3-(4-bromfenil)propan-3-on]-5-(supstituiranih fenil)-1,3,4-oksadiazola (4a-n) s ciljem da se dobiju spojevi s boljim protuupalnim i analgetskim, a manjim elcerogenim djelovanjem. Struktura sintetiziranih spojeva potvrđena je IR, 1H NMR i masenom spektroskopijom. Ispitano je protuupalno, analgetsko, ulcerogeno i antibakterijsko djelovanje spojeva 4a-n. Antibakterijsko djelovanje izraženo je kao minimalna inhibitorna koncentracija (MIC). Nekoliko spojeva imalo je značajno protuupalno i analgetsko djelovanje, nekoliko prilično antibakterijsko djelovanje, a svi su imali vrlo slabo ulcerogeno djelovanje. Rezultati ukazuju da ciklizacija karboksilne skupine u spoju 3 u 1,3,4-oksadiazol dovodi do povećanja protuupalnog i analgetskog, a do smanjenja ulcerogenog djelovanja.

Ključne riječi
1,3,4-oksadiazoli; aroilpropionska kiselina; protuupalno djelovanje; analgetsko djelovanje; antibakterijsko djelovanje

Hrčak ID: 33073

URI
https://hrcak.srce.hr/33073

[engleski]

Posjeta: 4.969 *