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https://doi.org/10.2478/v10007-009-0012-0

Ternary complexation of carvedilol, β-cyclodextrin and citric acid for mouth-dissolving tablet formulation

VARSHA POKHARKAR ; Department of Pharmaceutics, Bharati Vidyapeeth University, Poona College of Pharmacy, Erandwane, Pune-411038, Maharashtra, India
ABHISHEK KHANNA ; Department of Pharmaceutics, Bharati Vidyapeeth University, Poona College of Pharmacy, Erandwane, Pune-411038, Maharashtra, India
VINOD VENKATPURWAR ; Department of Pharmaceutics, Bharati Vidyapeeth University, Poona College of Pharmacy, Erandwane, Pune-411038, Maharashtra, India
SHEETAL DHAR ; Department of Pharmaceutics, Bharati Vidyapeeth University, Poona College of Pharmacy, Erandwane, Pune-411038, Maharashtra, India
LEENATA MANDPE ; Department of Pharmaceutics, Bharati Vidyapeeth University, Poona College of Pharmacy, Erandwane, Pune-411038, Maharashtra, India

Puni tekst: engleski, pdf (121 KB) str. 121-132 preuzimanja: 1.187* citiraj
APA 6th Edition
POKHARKAR, V., KHANNA, A., VENKATPURWAR, V., DHAR, S. i MANDPE, L. (2009). Ternary complexation of carvedilol, β-cyclodextrin and citric acid for mouth-dissolving tablet formulation. Acta Pharmaceutica, 59 (2), 121-132. https://doi.org/10.2478/v10007-009-0012-0
MLA 8th Edition
POKHARKAR, VARSHA, et al. "Ternary complexation of carvedilol, β-cyclodextrin and citric acid for mouth-dissolving tablet formulation." Acta Pharmaceutica, vol. 59, br. 2, 2009, str. 121-132. https://doi.org/10.2478/v10007-009-0012-0. Citirano 24.06.2019.
Chicago 17th Edition
POKHARKAR, VARSHA, ABHISHEK KHANNA, VINOD VENKATPURWAR, SHEETAL DHAR i LEENATA MANDPE. "Ternary complexation of carvedilol, β-cyclodextrin and citric acid for mouth-dissolving tablet formulation." Acta Pharmaceutica 59, br. 2 (2009): 121-132. https://doi.org/10.2478/v10007-009-0012-0
Harvard
POKHARKAR, V., et al. (2009). 'Ternary complexation of carvedilol, β-cyclodextrin and citric acid for mouth-dissolving tablet formulation', Acta Pharmaceutica, 59(2), str. 121-132. doi: https://doi.org/10.2478/v10007-009-0012-0
Vancouver
POKHARKAR V, KHANNA A, VENKATPURWAR V, DHAR S, MANDPE L. Ternary complexation of carvedilol, β-cyclodextrin and citric acid for mouth-dissolving tablet formulation. Acta Pharm. [Internet]. 2009 [pristupljeno 24.06.2019.];59(2):121-132. doi: https://doi.org/10.2478/v10007-009-0012-0
IEEE
V. POKHARKAR, A. KHANNA, V. VENKATPURWAR, S. DHAR i L. MANDPE, "Ternary complexation of carvedilol, β-cyclodextrin and citric acid for mouth-dissolving tablet formulation", Acta Pharmaceutica, vol.59, br. 2, str. 121-132, 2009. [Online]. doi: https://doi.org/10.2478/v10007-009-0012-0

Sažetak
The purpose of this study was to improve the solubility and dissolution rate of carvedilol by forming a ternary complex with β-cyclodextrin and citric acid and to formulate its mouth-dissolving tablets. The rationale for preparing mouth-dissolving tablet of carvedilol was to make the drug available in a soluble form in the mouth, which would facilitate its absorption from ther buccal cavity. Phase solubility studies revealed the ability of β-cyclodextrin and citric acid to complex with carvedilol and significantly increase its solubility. Ternary complexation of carvedilol was carried out with β-cyclodextrin and citric acid by physical mixing, kneading and spray drying methods and the prepared complexes were characterized by Fourier transform infra red spectroscopy, differential scanning calorimetry, powder X-ray diffractometry, scanning electron microscopy and complexation efficiency. The complex obtained by the spray drying method resulted in highest complexation efficiency and a 110-fold increase in the solubility of carvedilol. The mouth-dissolving tablets formulated using the spray dried complex with suitable excipients showed 100 % dissolution within five minutes. Accelerated stability studies of mouth dissolving tablets carried out as per ICH guidelines revealed that the tablets were stable.

Ključne riječi
carvedilol; cyclodextrin; citric acid; ternary complex; solubility; spray drying; mouth-dissolving tablet

Hrčak ID: 33501

URI
https://hrcak.srce.hr/33501

[hrvatski]

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