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https://doi.org/10.2478/v10007-009-0013-z

Production variables affecting characteristics of pellets in melt pelletization with wax combination in a laboratory scale spheronizer

SUDARSAN BISWAL ; Royal College of Pharmacy and Health Sciences, Andhapasarsa Road, Berhampur-760002 Orissa, India
JAGANNATH SAHOO ; Royal College of Pharmacy and Health Sciences, Andhapasarsa Road, Berhampur-760002 Orissa, India
PADALA NARASIMHAM MURTHY ; Royal College of Pharmacy and Health Sciences, Andhapasarsa Road, Berhampur-760002 Orissa, India
RAJESH PANDURANG GIRADKAR ; Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University Campus, Nagpur-440033, (M.S.), India
SUBASH DAS ; Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University Campus, Nagpur-440033, (M.S.), India
JASMINE GEV AVARI ; Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University Campus, Nagpur-440033, (M.S.), India

Puni tekst: engleski, pdf (325 KB) str. 199-210 preuzimanja: 777* citiraj
APA 6th Edition
BISWAL, S., SAHOO, J., MURTHY, P.N., GIRADKAR, R.P., DAS, S. i AVARI, J.G. (2009). Production variables affecting characteristics of pellets in melt pelletization with wax combination in a laboratory scale spheronizer. Acta Pharmaceutica, 59 (2), 199-210. https://doi.org/10.2478/v10007-009-0013-z
MLA 8th Edition
BISWAL, SUDARSAN, et al. "Production variables affecting characteristics of pellets in melt pelletization with wax combination in a laboratory scale spheronizer." Acta Pharmaceutica, vol. 59, br. 2, 2009, str. 199-210. https://doi.org/10.2478/v10007-009-0013-z. Citirano 16.06.2019.
Chicago 17th Edition
BISWAL, SUDARSAN, JAGANNATH SAHOO, PADALA NARASIMHAM MURTHY, RAJESH PANDURANG GIRADKAR, SUBASH DAS i JASMINE GEV AVARI. "Production variables affecting characteristics of pellets in melt pelletization with wax combination in a laboratory scale spheronizer." Acta Pharmaceutica 59, br. 2 (2009): 199-210. https://doi.org/10.2478/v10007-009-0013-z
Harvard
BISWAL, S., et al. (2009). 'Production variables affecting characteristics of pellets in melt pelletization with wax combination in a laboratory scale spheronizer', Acta Pharmaceutica, 59(2), str. 199-210. doi: https://doi.org/10.2478/v10007-009-0013-z
Vancouver
BISWAL S, SAHOO J, MURTHY PN, GIRADKAR RP, DAS S, AVARI JG. Production variables affecting characteristics of pellets in melt pelletization with wax combination in a laboratory scale spheronizer. Acta Pharm. [Internet]. 2009 [pristupljeno 16.06.2019.];59(2):199-210. doi: https://doi.org/10.2478/v10007-009-0013-z
IEEE
S. BISWAL, J. SAHOO, P.N. MURTHY, R.P. GIRADKAR, S. DAS i J.G. AVARI, "Production variables affecting characteristics of pellets in melt pelletization with wax combination in a laboratory scale spheronizer", Acta Pharmaceutica, vol.59, br. 2, str. 199-210, 2009. [Online]. doi: https://doi.org/10.2478/v10007-009-0013-z

Sažetak
The purpose of the study was to evaluate the suitability of laboratory scale spheronizer for the production of spherical pellets loaded with diltiazem hydrochloride by wax combination. The 1:1 combination of cetyl alcohol and hydrogenated castor oil, as low and high melting point waxes, were used. The various production variables affecting the different characteristics of pellets and the process efficiency were evaluated. Drug loaded pellets were evaluated for drug release in distilled water. Bowl temperature primarily affects the sphericity and adhesion of pellets to the bowl. Mass temperature has a pronounced effect on size, size distribution and sphericity of pellets. Wax concentration affects all characteristics of pellets but adhesion was least affected. The effect of these three variables can be compensated by optimizing the friction plate speed. It has been found that the highest yield of pellets (8501400 m) with maximum sphericity can be produced by using 45 C bowl temperature, 52 C mass temperature and 1400 rpm friction plate speed.

Ključne riječi
diltiazem hydrochloride; pellets; spheronizer; bowl temperature; cetyl alcohol; hydrogenated castor oil

Hrčak ID: 34087

URI
https://hrcak.srce.hr/34087

[hrvatski]

Posjeta: 1.162 *