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https://doi.org/10.2478/v10007-009-0014-y

Development of matrix controlled transdermal delivery systems of pentazocine: In vitro/in vivo performance

PRIYA RANJAN PRASAD VERMA ; Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi-835215, India
ASHOK R. CHANDAK ; Department of Pharmaceutical Sciences, Birla Institute of Technology, Mesra, Ranchi-835215, India

Puni tekst: engleski, pdf (174 KB) str. 171-186 preuzimanja: 1.244* citiraj
APA 6th Edition
VERMA, P.R.P. i CHANDAK, A.R. (2009). Development of matrix controlled transdermal delivery systems of pentazocine: In vitro/in vivo performance. Acta Pharmaceutica, 59 (2), 171-186. https://doi.org/10.2478/v10007-009-0014-y
MLA 8th Edition
VERMA, PRIYA RANJAN PRASAD i ASHOK R. CHANDAK. "Development of matrix controlled transdermal delivery systems of pentazocine: In vitro/in vivo performance." Acta Pharmaceutica, vol. 59, br. 2, 2009, str. 171-186. https://doi.org/10.2478/v10007-009-0014-y. Citirano 27.06.2019.
Chicago 17th Edition
VERMA, PRIYA RANJAN PRASAD i ASHOK R. CHANDAK. "Development of matrix controlled transdermal delivery systems of pentazocine: In vitro/in vivo performance." Acta Pharmaceutica 59, br. 2 (2009): 171-186. https://doi.org/10.2478/v10007-009-0014-y
Harvard
VERMA, P.R.P., i CHANDAK, A.R. (2009). 'Development of matrix controlled transdermal delivery systems of pentazocine: In vitro/in vivo performance', Acta Pharmaceutica, 59(2), str. 171-186. doi: https://doi.org/10.2478/v10007-009-0014-y
Vancouver
VERMA PRP, CHANDAK AR. Development of matrix controlled transdermal delivery systems of pentazocine: In vitro/in vivo performance. Acta Pharm. [Internet]. 2009 [pristupljeno 27.06.2019.];59(2):171-186. doi: https://doi.org/10.2478/v10007-009-0014-y
IEEE
P.R.P. VERMA i A.R. CHANDAK, "Development of matrix controlled transdermal delivery systems of pentazocine: In vitro/in vivo performance", Acta Pharmaceutica, vol.59, br. 2, str. 171-186, 2009. [Online]. doi: https://doi.org/10.2478/v10007-009-0014-y

Sažetak
The present study aimed to develop hydroxypropyl methylcellulose based transdermal delivery of pentazocine. In formulations containing lower proportions of polymer, the drug released followed the Higuchi kinetics while, with an increase in polymer content, it followed the zero-order release kinetics. Release exponent (n) values imply that the release of pentazocine from matrices was non-Fickian. FT-IR, DSC and XRD studies indicated no interaction between drug and polymer.
The in vitro dissolution rate constant, dissolution half-life and pharmacokinetic parameters (Cmax, tmax, AUC(s), t1/2, Kel, and MRT) were evaluated statistically by two-way ANOVA. A significant difference was observed between but not within the tested products. Statistically, a good correlation was found between per cent of drug absorbed from patches vs. Cmax, and AUC(s). A good correlation was also observed when per cent drug released was correlated with the blood drug concentration obtained at the same time point. The results of this study indicate that the polymeric matrix films of pentazocine hold potential for transdermal drug delivery.

Ključne riječi
pentazocine; transdermal drug delivery; Cygnusov flaster; in vitro characterization; in vivo evaluation

Hrčak ID: 34266

URI
https://hrcak.srce.hr/34266

[hrvatski]

Posjeta: 1.515 *