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Influence of PUVA and UVB Radiation on Expression of ICAM-1 and VCAM-1 Molecules in Psoriasis Vulgaris

Leo Čabrijan
Jasna Lipozenčić
Tanja Batinac
Maja Lenković
Zrinka Stanić Žgombić

Puni tekst: engleski, pdf (55 KB) str. 53-56 preuzimanja: 420* citiraj
APA 6th Edition
Čabrijan, L., Lipozenčić, J., Batinac, T., Lenković, M. i Stanić Žgombić, Z. (2008). Influence of PUVA and UVB Radiation on Expression of ICAM-1 and VCAM-1 Molecules in Psoriasis Vulgaris. Collegium antropologicum, 32 - Supplement 2 (2), 53-56. Preuzeto s https://hrcak.srce.hr/34540
MLA 8th Edition
Čabrijan, Leo, et al. "Influence of PUVA and UVB Radiation on Expression of ICAM-1 and VCAM-1 Molecules in Psoriasis Vulgaris." Collegium antropologicum, vol. 32 - Supplement 2, br. 2, 2008, str. 53-56. https://hrcak.srce.hr/34540. Citirano 15.06.2021.
Chicago 17th Edition
Čabrijan, Leo, Jasna Lipozenčić, Tanja Batinac, Maja Lenković i Zrinka Stanić Žgombić. "Influence of PUVA and UVB Radiation on Expression of ICAM-1 and VCAM-1 Molecules in Psoriasis Vulgaris." Collegium antropologicum 32 - Supplement 2, br. 2 (2008): 53-56. https://hrcak.srce.hr/34540
Harvard
Čabrijan, L., et al. (2008). 'Influence of PUVA and UVB Radiation on Expression of ICAM-1 and VCAM-1 Molecules in Psoriasis Vulgaris', Collegium antropologicum, 32 - Supplement 2(2), str. 53-56. Preuzeto s: https://hrcak.srce.hr/34540 (Datum pristupa: 15.06.2021.)
Vancouver
Čabrijan L, Lipozenčić J, Batinac T, Lenković M, Stanić Žgombić Z. Influence of PUVA and UVB Radiation on Expression of ICAM-1 and VCAM-1 Molecules in Psoriasis Vulgaris. Collegium antropologicum [Internet]. 2008 [pristupljeno 15.06.2021.];32 - Supplement 2(2):53-56. Dostupno na: https://hrcak.srce.hr/34540
IEEE
L. Čabrijan, J. Lipozenčić, T. Batinac, M. Lenković i Z. Stanić Žgombić, "Influence of PUVA and UVB Radiation on Expression of ICAM-1 and VCAM-1 Molecules in Psoriasis Vulgaris", Collegium antropologicum, vol.32 - Supplement 2, br. 2, str. 53-56, 2008. [Online]. Dostupno na: https://hrcak.srce.hr/34540. [Citirano: 15.06.2021.]

Sažetak
The expression of adhesion molecules Intercellular adhesion molecule-1(ICAM-1) and Vascular cell adhesion molecule-
1 (VCAM-1) is increased in lesional and in non-lesional skin of psoriatic patients, and play role in pathogenesis of
the disease. PUVA and UVB therapy are important treatments of psoriasis vulgaris. It has been demonstrated that UVA
and UVB therapies reduce expression of these molecules. In this investigation, phototherapy was used to treat psoriatic
patients. The expression of these molecules was examined by immunohistochemical method in lesional and non-lesional
skin of 10 patients with psoriasis vulgaris before and after treatment. Results showed increased expression of ICAM-1
molecules in keratinocytes, in perivascular infiltrate – lymphocytes, and in endothelial cells. The expression of VCAM-1
molecules was also increased, although with less intensity then ICAM-1. After therapy, the expression of the adhesion
molecules decreased together with a marked improvement of the disease. In conclusion, study demonstrated that phototherapy
improves psoriasis vulgaris probably through mechanisms acting on the adhesions molecules. Adverse reactions
due to intense or long lasting UVA (PUVA) and UVB therapies are immunosuppression and damage of DNA which
can lead to development of non-melanocytic skin tumors like basal cell carcinoma and squamous cell carcinoma, as well
as melanoma.

Ključne riječi
psoriasis; UV treatment; ICAM-1; VCAM-1

Hrčak ID: 34540

URI
https://hrcak.srce.hr/34540

Posjeta: 636 *