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Fractionated Illumination Improves the Outcome in the Treatment of Precancerous Lesions with Photodynamic Therapy

Neira Puizina-Ivić
Hrvoje Zorc
Lucija Vanjaka-Rogošić
Lina Mirić
Antun Peršin

Puni tekst: engleski, pdf (342 KB) str. 67-73 preuzimanja: 624* citiraj
APA 6th Edition
Puizina-Ivić, N., Zorc, H., Vanjaka-Rogošić, L., Mirić, L. i Peršin, A. (2008). Fractionated Illumination Improves the Outcome in the Treatment of Precancerous Lesions with Photodynamic Therapy. Collegium antropologicum, 32 - Supplement 2 (2), 67-73. Preuzeto s https://hrcak.srce.hr/34543
MLA 8th Edition
Puizina-Ivić, Neira, et al. "Fractionated Illumination Improves the Outcome in the Treatment of Precancerous Lesions with Photodynamic Therapy." Collegium antropologicum, vol. 32 - Supplement 2, br. 2, 2008, str. 67-73. https://hrcak.srce.hr/34543. Citirano 16.06.2021.
Chicago 17th Edition
Puizina-Ivić, Neira, Hrvoje Zorc, Lucija Vanjaka-Rogošić, Lina Mirić i Antun Peršin. "Fractionated Illumination Improves the Outcome in the Treatment of Precancerous Lesions with Photodynamic Therapy." Collegium antropologicum 32 - Supplement 2, br. 2 (2008): 67-73. https://hrcak.srce.hr/34543
Harvard
Puizina-Ivić, N., et al. (2008). 'Fractionated Illumination Improves the Outcome in the Treatment of Precancerous Lesions with Photodynamic Therapy', Collegium antropologicum, 32 - Supplement 2(2), str. 67-73. Preuzeto s: https://hrcak.srce.hr/34543 (Datum pristupa: 16.06.2021.)
Vancouver
Puizina-Ivić N, Zorc H, Vanjaka-Rogošić L, Mirić L, Peršin A. Fractionated Illumination Improves the Outcome in the Treatment of Precancerous Lesions with Photodynamic Therapy. Collegium antropologicum [Internet]. 2008 [pristupljeno 16.06.2021.];32 - Supplement 2(2):67-73. Dostupno na: https://hrcak.srce.hr/34543
IEEE
N. Puizina-Ivić, H. Zorc, L. Vanjaka-Rogošić, L. Mirić i A. Peršin, "Fractionated Illumination Improves the Outcome in the Treatment of Precancerous Lesions with Photodynamic Therapy", Collegium antropologicum, vol.32 - Supplement 2, br. 2, str. 67-73, 2008. [Online]. Dostupno na: https://hrcak.srce.hr/34543. [Citirano: 16.06.2021.]

Sažetak
Photodynamic therapy (PDT) is a noninvasive therapy for non-melanoma skin cancer. The aim of this study was comparison
of efficacy between fractioned versus single dose illumination in photodynamic therapy (PDT) of actinic keratosis
(AK) and Bowen’s disease (BD). Fifty-one patients (36 AK and 15 BD) were treated with PDT. They were randomly
arranged in two treatment groups. Group one included 26 patients (20 AK and 6 BD) that, after five hours of incubation
with 20% 5-ALA, were treated with a single illumination of 100 Jcm–2 at fluence rate of 30 mWcm–2. Group two included
25 patients (16 AK and 9 BD) that, after 16 hours of incubation with 20% 5-ALA, were treated with two light fractions
(50 plus 50 Jcm–2) at same fluence rate with dark interval of two hours between fractions. Twenty-four weeks later, a
treated area was incubated for four hours again with 5-ALA in order to detect occult areas of abnormal skin with possible
remaining tumor tissue. In case of fluorescence, histological examination was performed. In the group one, fluorescence
at the end of the session was absent in 19 (73%) or very weak in 7 (27%). Residual tumor was found in 15 (75%) AK and
in 4 (66.6%) BD. In the group two, fluorescence at the end of second session was more intense; in one patient (4%) was absent,
very weak in 5 (20%) and weak in 19 (76%) of patients. In this group histology revealed remaining tumor tissue in
only 2 (12.5%) AK and 2 (22.2%) BD. Among the patients in the first group, the remaining tumor tissue was significantly
bigger (p=0.005). The treatment response with clearing of tumor tissue was significantly higher in fractionated illumination
than in a single dose illumination group. Fractionated illumination scheme with 16 hours of incubation separated
by two hours dark interval significantly improves the therapeutic outcome in tumor eradication.

Ključne riječi
topical photodynamic therapy; 5-ALA; fractionated illumination

Hrčak ID: 34543

URI
https://hrcak.srce.hr/34543

Posjeta: 821 *