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Expression of Bone Morphogenetic Proteins, Cartilage-Derived Morphogenetic Proteins and Related Receptors in Normal and Osteoarthritic Human Articular Cartilage

Dragica Bobinac
Josip Španjol
Marin Marinović
Sanja Zoričić Cvek
Ivana Marić
Tedi Cicvarić
Dora Fučkar
Dean Markić
Božidar Vojniković

Puni tekst: engleski, pdf (135 KB) str. 83-87 preuzimanja: 543* citiraj
APA 6th Edition
Bobinac, D., Španjol, J., Marinović, M., Zoričić Cvek, S., Marić, I., Cicvarić, T., ... Vojniković, B. (2008). Expression of Bone Morphogenetic Proteins, Cartilage-Derived Morphogenetic Proteins and Related Receptors in Normal and Osteoarthritic Human Articular Cartilage. Collegium antropologicum, 32 - Supplement 2 (2), 83-87. Preuzeto s https://hrcak.srce.hr/34546
MLA 8th Edition
Bobinac, Dragica, et al. "Expression of Bone Morphogenetic Proteins, Cartilage-Derived Morphogenetic Proteins and Related Receptors in Normal and Osteoarthritic Human Articular Cartilage." Collegium antropologicum, vol. 32 - Supplement 2, br. 2, 2008, str. 83-87. https://hrcak.srce.hr/34546. Citirano 20.06.2021.
Chicago 17th Edition
Bobinac, Dragica, Josip Španjol, Marin Marinović, Sanja Zoričić Cvek, Ivana Marić, Tedi Cicvarić, Dora Fučkar, Dean Markić i Božidar Vojniković. "Expression of Bone Morphogenetic Proteins, Cartilage-Derived Morphogenetic Proteins and Related Receptors in Normal and Osteoarthritic Human Articular Cartilage." Collegium antropologicum 32 - Supplement 2, br. 2 (2008): 83-87. https://hrcak.srce.hr/34546
Harvard
Bobinac, D., et al. (2008). 'Expression of Bone Morphogenetic Proteins, Cartilage-Derived Morphogenetic Proteins and Related Receptors in Normal and Osteoarthritic Human Articular Cartilage', Collegium antropologicum, 32 - Supplement 2(2), str. 83-87. Preuzeto s: https://hrcak.srce.hr/34546 (Datum pristupa: 20.06.2021.)
Vancouver
Bobinac D, Španjol J, Marinović M, Zoričić Cvek S, Marić I, Cicvarić T i sur. Expression of Bone Morphogenetic Proteins, Cartilage-Derived Morphogenetic Proteins and Related Receptors in Normal and Osteoarthritic Human Articular Cartilage. Collegium antropologicum [Internet]. 2008 [pristupljeno 20.06.2021.];32 - Supplement 2(2):83-87. Dostupno na: https://hrcak.srce.hr/34546
IEEE
D. Bobinac, et al., "Expression of Bone Morphogenetic Proteins, Cartilage-Derived Morphogenetic Proteins and Related Receptors in Normal and Osteoarthritic Human Articular Cartilage", Collegium antropologicum, vol.32 - Supplement 2, br. 2, str. 83-87, 2008. [Online]. Dostupno na: https://hrcak.srce.hr/34546. [Citirano: 20.06.2021.]

Sažetak
Newborn and adult articular cartilage expresses bone (BMPs) and cartilage derived morphogenetic proteins (CDMPs).
These morphogenetic proteins act over membrane receptors (BMPRs). We examined the expression pattern of BMP-7,
BMP-3, CDMP-1, CDMP-2 and their receptors in adult normal and osteoarthritic, articular, knee cartilage. Immunostaining
was carried out using polyclonal antibodies. The expression of BMP-7,-3, CDMP-1,-2 was detected in all layers
of normal articular cartilage with the strongest expression in chondrocytes of the transitional layer. BMP-7 and CDMPs
expression decreased in osteoarthritic articular cartilage whereas BMP-3 expression was absent. BMPR-IA and BMPR-II
were strongly expressed in both normal and osteoarthritic articular cartilage. BMPR-IB was not expressed in osteoarthritic
(OA) cartilage. BMPs and CDMPs with intact signalling play an important role in articular cartilage homeostasis,
preventing cartilage degeneration.

Ključne riječi
articular cartilage; bone morphogenetic proteins; cartilage derived morphogenetic proteins; osteoarthritis

Hrčak ID: 34546

URI
https://hrcak.srce.hr/34546

Posjeta: 735 *