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Increase in Lactate Dehydrogenase Isoenzyme-4 and Splenocyte Toxicity in Methomyl-Treated Rats

Ornrat Lohitnavy
Palarp Sinhaseni

Puni tekst: engleski, pdf (322 KB) str. 231-238 preuzimanja: 1.171* citiraj
APA 6th Edition
Lohitnavy, O. i Sinhaseni, P. (1998). Increase in Lactate Dehydrogenase Isoenzyme-4 and Splenocyte Toxicity in Methomyl-Treated Rats. Arhiv za higijenu rada i toksikologiju, 49 (3), 231-238. Preuzeto s https://hrcak.srce.hr/3280
MLA 8th Edition
Lohitnavy, Ornrat i Palarp Sinhaseni. "Increase in Lactate Dehydrogenase Isoenzyme-4 and Splenocyte Toxicity in Methomyl-Treated Rats." Arhiv za higijenu rada i toksikologiju, vol. 49, br. 3, 1998, str. 231-238. https://hrcak.srce.hr/3280. Citirano 20.08.2019.
Chicago 17th Edition
Lohitnavy, Ornrat i Palarp Sinhaseni. "Increase in Lactate Dehydrogenase Isoenzyme-4 and Splenocyte Toxicity in Methomyl-Treated Rats." Arhiv za higijenu rada i toksikologiju 49, br. 3 (1998): 231-238. https://hrcak.srce.hr/3280
Harvard
Lohitnavy, O., i Sinhaseni, P. (1998). 'Increase in Lactate Dehydrogenase Isoenzyme-4 and Splenocyte Toxicity in Methomyl-Treated Rats', Arhiv za higijenu rada i toksikologiju, 49(3), str. 231-238. Preuzeto s: https://hrcak.srce.hr/3280 (Datum pristupa: 20.08.2019.)
Vancouver
Lohitnavy O, Sinhaseni P. Increase in Lactate Dehydrogenase Isoenzyme-4 and Splenocyte Toxicity in Methomyl-Treated Rats. Arh Hig Rada Toksikol. [Internet]. 1998 [pristupljeno 20.08.2019.];49(3):231-238. Dostupno na: https://hrcak.srce.hr/3280
IEEE
O. Lohitnavy i P. Sinhaseni, "Increase in Lactate Dehydrogenase Isoenzyme-4 and Splenocyte Toxicity in Methomyl-Treated Rats", Arhiv za higijenu rada i toksikologiju, vol.49, br. 3, str. 231-238, 1998. [Online]. Dostupno na: https://hrcak.srce.hr/3280. [Citirano: 20.08.2019.]

Sažetak
The toxic effect of methomyl was studied in rats after a single or repeated oral administration. Rats treated with a single dose of methomyl (3, 5, or 7 mg/kg) showed significant increase (P<0.05) in total lactate dehydrogenase activity on day 1. The highest level of LDH activity was observed on day 3 in rats receiving 7 mg/kg of methomyl. The total LDH activity returned to normal on day 7 after dosing. Specific increases in LDH-3 and LDH-4 isoenzyme activities were observed. In rats treated with a single dose of 6 and 8 mg/kg of methomyl, spleen weight and splenocyte viability significantly dropped (P<0.05) on days 1 and 3, respectively. Splenotoxicity was prevented by pretreatment with 60 mg/kg of N-acetylcysteine. The results suggest that the splenotoxic effect of methomyl is more likely directly related to oxidative cell injury than to cholinesterase inhibition. The significance of cytotoxic effects and the nature of cytotoxicity in relation to reactive oxidative damage deserve further investigation.

Ključne riječi
carbamates; cholinesterases; insecticides; lactate dehydrogenase; methomyl; rats; spelnocyte; splenotoxicity

Hrčak ID: 3280

URI
https://hrcak.srce.hr/3280

[hrvatski]

Posjeta: 1.763 *