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Arhiv za higijenu rada i toksikologiju, Vol. 49 No. 2, 1998.

Izvorni znanstveni članak

Meso-2,3-dimercaptosuccinic Acid in the Treatment of Occupational Exposed Lead workers

Nada Restek-Samaržija
Maja Blanuša
Alica Pizent
Miroslav Samaržija
Rajka Turk
Naima Čorović
Jasna Jurasović

Puni tekst: engleski, pdf (3 MB) str. 137-145 preuzimanja: 763* citiraj
APA 6th Edition
Restek-Samaržija, N., Blanuša, M., Pizent, A., Samaržija, M., Turk, R., Čorović, N. i Jurasović, J. (1998). Meso-2,3-dimercaptosuccinic Acid in the Treatment of Occupational Exposed Lead workers. Arhiv za higijenu rada i toksikologiju, 49 (2), 137-145. Preuzeto s https://hrcak.srce.hr/3309
MLA 8th Edition
Restek-Samaržija, Nada, et al. "Meso-2,3-dimercaptosuccinic Acid in the Treatment of Occupational Exposed Lead workers." Arhiv za higijenu rada i toksikologiju, vol. 49, br. 2, 1998, str. 137-145. https://hrcak.srce.hr/3309. Citirano 22.02.2019.
Chicago 17th Edition
Restek-Samaržija, Nada, Maja Blanuša, Alica Pizent, Miroslav Samaržija, Rajka Turk, Naima Čorović i Jasna Jurasović. "Meso-2,3-dimercaptosuccinic Acid in the Treatment of Occupational Exposed Lead workers." Arhiv za higijenu rada i toksikologiju 49, br. 2 (1998): 137-145. https://hrcak.srce.hr/3309
Harvard
Restek-Samaržija, N., et al. (1998). 'Meso-2,3-dimercaptosuccinic Acid in the Treatment of Occupational Exposed Lead workers', Arhiv za higijenu rada i toksikologiju, 49(2), str. 137-145. Preuzeto s: https://hrcak.srce.hr/3309 (Datum pristupa: 22.02.2019.)
Vancouver
Restek-Samaržija N, Blanuša M, Pizent A, Samaržija M, Turk R, Čorović N i sur. Meso-2,3-dimercaptosuccinic Acid in the Treatment of Occupational Exposed Lead workers. Arh Hig Rada Toksikol. [Internet]. 1998 [pristupljeno 22.02.2019.];49(2):137-145. Dostupno na: https://hrcak.srce.hr/3309
IEEE
N. Restek-Samaržija, et al., "Meso-2,3-dimercaptosuccinic Acid in the Treatment of Occupational Exposed Lead workers", Arhiv za higijenu rada i toksikologiju, vol.49, br. 2, str. 137-145, 1998. [Online]. Dostupno na: https://hrcak.srce.hr/3309. [Citirano: 22.02.2019.]

Sažetak
The aim of this study was to evaluate the efficacy of (DMSA) meso-2,3-dimercaptosuccinic acid treatment in workers with increased lead absorption and no overt symptoms of lead poisoning. Seven occupationally lead exposed male workers with blood lead concentrations (PbB) exceeding 50 µg/100 ml and a positive (EDTA) calcium disodium ethylenediaminetetraacetate lead mobilization test were treated with DMSA for 19 days. Individual doses were 700 mg DMSA, three times a day from day one to five, and twice a day from day six to 19. The treatment intensified urinary lead excretion, most rapidly during the first five days. The increased elimination was followed by a decline of mean PbB to 15% of the pretreatment values. However, 15 days after the treatment, the PbB concentrations rebounded, yet kept below the baseline values and did not exceed 40 µg/100 ml. After repeated EDTA lead mobilization test, urine lead was 23–68% of that before DMSA treatment. It can be concluded that DMSA can effectively reduce chelatable lead in occupationally exposed workers.

Ključne riječi
blood; calcium; CaNa2EDTA; chelation therapy; copper; iron; lead; magnesium; meso-2,3-dimercaptosuccinic acid; mobilisation test; occupational exposed; urine; workers; zinc

Hrčak ID: 3309

URI
https://hrcak.srce.hr/3309

[hrvatski]

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