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Meso-2,3-dimercaptosuccinic Acid in the Treatment of Occupational Exposed Lead workers

Nada Restek-Samaržija
Maja Blanuša
Alica Pizent
Miroslav Samaržija
Rajka Turk
Naima Čorović
Jasna Jurasović


Puni tekst: engleski pdf 2.782 Kb

str. 137-145

preuzimanja: 1.144

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Sažetak

The aim of this study was to evaluate the efficacy of (DMSA) meso-2,3-dimercaptosuccinic acid treatment in workers with increased lead absorption and no overt symptoms of lead poisoning. Seven occupationally lead exposed male workers with blood lead concentrations (PbB) exceeding 50 µg/100 ml and a positive (EDTA) calcium disodium ethylenediaminetetraacetate lead mobilization test were treated with DMSA for 19 days. Individual doses were 700 mg DMSA, three times a day from day one to five, and twice a day from day six to 19. The treatment intensified urinary lead excretion, most rapidly during the first five days. The increased elimination was followed by a decline of mean PbB to 15% of the pretreatment values. However, 15 days after the treatment, the PbB concentrations rebounded, yet kept below the baseline values and did not exceed 40 µg/100 ml. After repeated EDTA lead mobilization test, urine lead was 23–68% of that before DMSA treatment. It can be concluded that DMSA can effectively reduce chelatable lead in occupationally exposed workers.

Ključne riječi

blood; calcium; CaNa2EDTA; chelation therapy; copper; iron; lead; magnesium; meso-2,3-dimercaptosuccinic acid; mobilisation test; occupational exposed; urine; workers; zinc

Hrčak ID:

3309

URI

https://hrcak.srce.hr/3309

Datum izdavanja:

17.12.1998.

Podaci na drugim jezicima: hrvatski

Posjeta: 2.078 *