Izvorni znanstveni članak
Effects of Gamma-Radiation on Ovarian Follicles
Young-Keun Lee
Hwa-Hyoung Chang
Won-Rok Kim
Jin Kyu Kim
Yong-Dal Yoon
Sažetak
In order to observe the morphological and endocrinological changes of the rat and mouse ovarian follicles by gamma-radiation, rats were whole-body irradiated with doses of 3.2 Gy and 8.0 Gy and mice with 2.9 Gy and 7.2 Gy. Sections of ovaria were examined by light microscopy. Concentrations of progesterone, testosterone, and estradiol in ovarian homogenate were determined by radioimmunoassay techniques. Gamma-radiation resulted in the increased percentage of atretic follicles in the groups killed on day 0, day 4, and day 8 after irradiation. The decrease in granulosa cell viability was found in animals killed on day 4 after irradiation. The finding of the high ratio of testosterone to estradiol compared to that of progesterone to testosterone suggests that aromatase activity — steroid biosynthesis from testosterone to estradiol — in granulosa cell could be affected by gamma-radiation.
Ključne riječi
estradiol; gamma-radiation; mice; ovarian follicles; ovarian histology; progesterone; rats; testosterone
Hrčak ID:
3310
URI
Datum izdavanja:
17.12.1998.
Posjeta: 2.412 *