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Acta Pharmaceutica, Vol. 59 No. 2, 2009.

Izvorni znanstveni članak
https://doi.org/10.2478/v10007-009-0016-9

Synthesis of certain pyrrole derivatives as antimicrobial agents

MOSAAD SAYED MOHAMED ; Organic Chemistry Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt
RAMDAN AHMED EL-DOMANY ; Microbiology and Immunology Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt
RANIA HELMY ABD EL-HAMEED ; Organic Chemistry Department, Faculty of Pharmacy, Helwan University, Cairo, Egypt

Puni tekst: engleski, pdf (97 KB) str. 145-158 preuzimanja: 1.803* citiraj
APA 6th Edition
SAYED MOHAMED, M., EL-DOMANY, R.A. i ABD EL-HAMEED, R.H. (2009). Synthesis of certain pyrrole derivatives as antimicrobial agents. Acta Pharmaceutica, 59 (2), 145-158. https://doi.org/10.2478/v10007-009-0016-9
MLA 8th Edition
SAYED MOHAMED, MOSAAD, et al. "Synthesis of certain pyrrole derivatives as antimicrobial agents." Acta Pharmaceutica, vol. 59, br. 2, 2009, str. 145-158. https://doi.org/10.2478/v10007-009-0016-9. Citirano 20.02.2019.
Chicago 17th Edition
SAYED MOHAMED, MOSAAD, RAMDAN AHMED EL-DOMANY i RANIA HELMY ABD EL-HAMEED. "Synthesis of certain pyrrole derivatives as antimicrobial agents." Acta Pharmaceutica 59, br. 2 (2009): 145-158. https://doi.org/10.2478/v10007-009-0016-9
Harvard
SAYED MOHAMED, M., EL-DOMANY, R.A., i ABD EL-HAMEED, R.H. (2009). 'Synthesis of certain pyrrole derivatives as antimicrobial agents', Acta Pharmaceutica, 59(2), str. 145-158. doi: https://doi.org/10.2478/v10007-009-0016-9
Vancouver
SAYED MOHAMED M, EL-DOMANY RA, ABD EL-HAMEED RH. Synthesis of certain pyrrole derivatives as antimicrobial agents. Acta Pharm. [Internet]. 2009 [pristupljeno 20.02.2019.];59(2):145-158. doi: https://doi.org/10.2478/v10007-009-0016-9
IEEE
M. SAYED MOHAMED, R.A. EL-DOMANY i R.H. ABD EL-HAMEED, "Synthesis of certain pyrrole derivatives as antimicrobial agents", Acta Pharmaceutica, vol.59, br. 2, str. 145-158, 2009. [Online]. doi: https://doi.org/10.2478/v10007-009-0016-9

Sažetak
In an effort to establish new pyrroles and pyrrolo[2,3-d]pyrimidines with improved antimicrobial activity we report here the synthesis and in vitro microbiological evaluation of a series of pyrrole derivatives. A series of new 2-aminopyrrole-3-carbonitriles (1a-d) were synthesized from the reaction of benzoin, primary aromatic amines and malononitrile, from which a number of pyrrole derivatives (2a-d to 5a-d) and pyrrolo[2,3-d]pyrimidines (6a-d to 10a,d) were synthesized. The in vitro antimicrobial testing of the synthesized compounds was carried out against Gram-positive, Gram-negative bacteria and fungi. Some of the prepared compounds, [2-amino-1-(2-methylphenyl)-4,5-diphenyl-1H-pyrrole-3-carbonitrile (1b), 2-amino-3-carbamoyl-1-(3-methylphenyl)-4,5-diphenyl-1H-pyrrole (2b), N-(3-cyano-1-(2-methylphenyl)-4,5-diphenyl-1H-pyrrol-2-yl)-acetamide (3b), N-(3-cyano-1-(3-methylphenyl)-4,5-diphenyl-1H-pyrrol-2-yl)-acetamide (3c), 2-amino-1-(4-methoxyphenyl)-4,5-diphenyl-3-tetrazolo-1H-pyrrole (5d), 7-(4-methoxyphenyl)-5,6-diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4(3H)-one (7d), 7(3-methylphenyl)-5,6-diphenyl-7H-pyrrolo[2,3-d]pyrimidin-4(3H)-thion (9b) and N-(7-(2-methylphenyl)-5,6-diphenyl-7H-pyrrolo[2,3-d]pyrimidine)-N-aryl amine (10a)] showed potent antimicrobial activity.

Ključne riječi
pyrrole; pyrrolopyrimidine; antimicrobial activity

Hrčak ID: 35239

URI
https://hrcak.srce.hr/35239

[hrvatski]

Posjeta: 2.171 *