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https://doi.org/10.2478/v10007-009-0019-6

Development and evaluation of gastroretentive norfloxacin floating tablets

RAMESH BOMMA ; University College of Pharmaceutical Sciences, Kakatiya University, Warangal-506009 (A.P.), India
RONGALA APPALA SWAMY NAIDU ; Natco Pharma Ltd., Kotthur, Mahaboobnagar District, India
MADHUSUDAN RAO YAMSANI ; University College of Pharmaceutical Sciences, Kakatiya University, Warangal-506009 (A.P.), India
KISHAN VEERABRAHMA ; University College of Pharmaceutical Sciences, Kakatiya University, Warangal-506009 (A.P.), India


Puni tekst: engleski pdf 99 Kb

str. 211-221

preuzimanja: 2.622

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Sažetak

Floating matrix tablets of norfloxacin were developed to prolong gastric residence time, leading to an increase in drug bioavailability. Tablets were prepared by the wet granulation technique, using polymers such as hydroxy propyl methylcellulose (HPMCK4M, HPMCK100M) and xanthan gum. Tablets were evaluated for their physical characteristics viz., hardness, thickness, friability, and mass variation, drug content and floating properties. Further, tablets were studied for in vitro drug release characteristics for 9 hours. The tablets exhibited controlled and prolonged drug release profiles while floating over the dissolution medium. Non-Fickian diffusion was confirmed as the drug release mechanism from these tablets, indicating that water diffusion and the polymer rearrangement played an essential role in drug release. The best formulation (F4) was selected based on in vitro characteristics and was used in vivo radiographic studies by incorporating BaSO4. These studies revealed that the tablets remained in the stomach for 180 ± 30 min in fasting human volunteers and indicated that gastric retention time was increased by the floating principle, which was considered desirable for absorption window drugs.

Ključne riječi

norfloxacin; floating tablets; gastric residence time; gastroretentive drug delivery system

Hrčak ID:

36096

URI

https://hrcak.srce.hr/36096

Datum izdavanja:

1.6.2009.

Podaci na drugim jezicima: hrvatski

Posjeta: 4.184 *