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Acta Pharmaceutica, Vol. 59 No. 2, 2009.

Izvorni znanstveni članak
https://doi.org/10.2478/v10007-009-0020-0

Priprava pegiliranih nano-liposomskih formulacija sa SN-38: In vitro karakterizacija i in vivo biodistribucija u miševa

FATEMEH ATYABI ; Novel Drug Delivery Systems Laboratory, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, PO Box 14155-6451, Islamic Republic of Iran
ANAHITA FARKHONDEHFAL ; Medical Nanotechnology Research Centre, Tehran University of Medical Sciences, Tehran, PO Box 14155-6451, Islamic Republic of Iran
FARNAZ ESMAEILI ; Novel Drug Delivery Systems Laboratory, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, PO Box 14155-6451, Islamic Republic of Iran
RASSOUL DINARVAND ; Novel Drug Delivery Systems Laboratory, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, PO Box 14155-6451, Islamic Republic of Iran

Puni tekst: engleski, pdf (160 KB) str. 133-144 preuzimanja: 1.495* citiraj
APA 6th Edition
ATYABI, F., FARKHONDEHFAL, A., ESMAEILI, F. i DINARVAND, R. (2009). Preparation of pegylated nano-liposomal formulation containing SN-38: In vitro characterization and in vivo biodistribution in mice. Acta Pharmaceutica, 59 (2), 133-144. https://doi.org/10.2478/v10007-009-0020-0
MLA 8th Edition
ATYABI, FATEMEH, et al. "Preparation of pegylated nano-liposomal formulation containing SN-38: In vitro characterization and in vivo biodistribution in mice." Acta Pharmaceutica, vol. 59, br. 2, 2009, str. 133-144. https://doi.org/10.2478/v10007-009-0020-0. Citirano 17.02.2019.
Chicago 17th Edition
ATYABI, FATEMEH, ANAHITA FARKHONDEHFAL, FARNAZ ESMAEILI i RASSOUL DINARVAND. "Preparation of pegylated nano-liposomal formulation containing SN-38: In vitro characterization and in vivo biodistribution in mice." Acta Pharmaceutica 59, br. 2 (2009): 133-144. https://doi.org/10.2478/v10007-009-0020-0
Harvard
ATYABI, F., et al. (2009). 'Preparation of pegylated nano-liposomal formulation containing SN-38: In vitro characterization and in vivo biodistribution in mice', Acta Pharmaceutica, 59(2), str. 133-144. doi: https://doi.org/10.2478/v10007-009-0020-0
Vancouver
ATYABI F, FARKHONDEHFAL A, ESMAEILI F, DINARVAND R. Preparation of pegylated nano-liposomal formulation containing SN-38: In vitro characterization and in vivo biodistribution in mice. Acta Pharm. [Internet]. 2009 [pristupljeno 17.02.2019.];59(2):133-144. doi: https://doi.org/10.2478/v10007-009-0020-0
IEEE
F. ATYABI, A. FARKHONDEHFAL, F. ESMAEILI i R. DINARVAND, "Preparation of pegylated nano-liposomal formulation containing SN-38: In vitro characterization and in vivo biodistribution in mice", Acta Pharmaceutica, vol.59, br. 2, str. 133-144, 2009. [Online]. doi: https://doi.org/10.2478/v10007-009-0020-0

Sažetak
7-Etil-10-hidroksi-kamptotecin (SN38), metabolit irinotekan hidroklorida, vrlo je slabo topljiv u vodenim otopinama i praktički netopljiv u većini fiziološki kompatibilnih i farmaceutski prihvatljivih otapala. Poradi toga je veoma teško formuliranje supstancije SN38 u koncentrirane sustave za parenteralnu primjenu. Liposomi se zbog svoje biokompatibilnosti i niske toksičnosti čine pogodnim za isporuku SN38. U ovom radu opisana je priprava pegiliranih liposoma sa SN38 pomoću distearoilfosfatidilkolina i distearoilfosfatidiletanolamina. Pripravljenim liposomima određena je veličina čestica, sposobnost inkapsuliranja, in vitro oslobađanje i biodistribucija. Veličina čestica liposoma bila je u rasponu 150200 nm. Sposobnost kapsuliranja i in vitro oslobađanje pegiliranih liposoma bila je veća nego nepegiliranih liposoma. Kao što se očekivalo, distribucija pegiliranih liposoma u jetri, bubregu, slezeni i plućima bila je značajno niža nego nepegiliranih liposoma. Njihova koncentracija u krvi bila je najmanje 50 % viša od nepegiliranih liposoma.

Ključne riječi
nanočestice; SN38; pegilirani liposomi; PEG; biodistribucija; isporuka lijeka

Hrčak ID: 36718

URI
https://hrcak.srce.hr/36718

[engleski]

Posjeta: 1.779 *