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Chemistry and Biological Effects of Gliotoxin

Ivan Kosalec
Stjepan Pepeljnjak

Puni tekst: hrvatski, pdf (364 KB) str. 313-320 preuzimanja: 1.055* citiraj
APA 6th Edition
Kosalec, I. i Pepeljnjak, S. (2004). Kemizam i biološki učinci gliotoksina. Arhiv za higijenu rada i toksikologiju, 55 (4), 313-320. Preuzeto s https://hrcak.srce.hr/260
MLA 8th Edition
Kosalec, Ivan i Stjepan Pepeljnjak. "Kemizam i biološki učinci gliotoksina." Arhiv za higijenu rada i toksikologiju, vol. 55, br. 4, 2004, str. 313-320. https://hrcak.srce.hr/260. Citirano 26.06.2019.
Chicago 17th Edition
Kosalec, Ivan i Stjepan Pepeljnjak. "Kemizam i biološki učinci gliotoksina." Arhiv za higijenu rada i toksikologiju 55, br. 4 (2004): 313-320. https://hrcak.srce.hr/260
Harvard
Kosalec, I., i Pepeljnjak, S. (2004). 'Kemizam i biološki učinci gliotoksina', Arhiv za higijenu rada i toksikologiju, 55(4), str. 313-320. Preuzeto s: https://hrcak.srce.hr/260 (Datum pristupa: 26.06.2019.)
Vancouver
Kosalec I, Pepeljnjak S. Kemizam i biološki učinci gliotoksina. Arh Hig Rada Toksikol. [Internet]. 2004 [pristupljeno 26.06.2019.];55(4):313-320. Dostupno na: https://hrcak.srce.hr/260
IEEE
I. Kosalec i S. Pepeljnjak, "Kemizam i biološki učinci gliotoksina", Arhiv za higijenu rada i toksikologiju, vol.55, br. 4, str. 313-320, 2004. [Online]. Dostupno na: https://hrcak.srce.hr/260. [Citirano: 26.06.2019.]

Sažetak
Gliotoxin is a mycotoxin from the epipolythiodioxypipeazine family with biological active internal disulfide bridge. Gliotoxin has an antibacterial and antiviral activity, but it was discarded from clinical practice due to its toxicity. The most studied effect of gliotoxin is its influence on the cell of the immune system. Today, researches are focused on treating transplantation organs ex situ and making them immunologically silent. Its toxicity has been proven on several cells (macrophages, thymocites, splenocytes, and fibroblasts) causing apoptosis and necrosis and it has acted as inhibitor of several enzymes (farnesyl-transefases, NF-κB, and alcohol-dehydrogenases). Its mechanism of toxicity is connected with the production of mixed disulfide and covalent bonds, and oxidative effects. An important medical mould Aspergillus fumigatus and yeast Candida albicans can secrete gliotoxin in infected tissues and, because of the proven toxic effects of gliotoxin, it is suggested that gliotoxin can exacerbate mycoses (invasive aspergillosis or candidiasis). Gliotoxin can also affect the invasiveness of fungi and their dissemination from the primary site throughout the organism.

Ključne riječi
Aspergillus fumigatus; Candida albicans; fungi; moulds; mycotoxin

Hrčak ID: 260

URI
https://hrcak.srce.hr/260

[hrvatski]

Posjeta: 1.465 *