Acta Pharmaceutica, Vol. 59 No. 3, 2009.
Izvorni znanstveni članak
https://doi.org/10.2478/v10007-009-0025-8
Effects of drug solubility on the release kinetics of water soluble and insoluble drug from HPMC based matrix formulations
SANTANU CHAKRABORTY
MADHUSMRUTI KHANDAI
; P.G. Department of Pharmaceutics, College of Pharmaceutical Sciences, Berhampur – 760002, Orissa, India
ANURADHA SHARMA
; P.G. Department of Pharmaceutics, College of Pharmaceutical Sciences, Berhampur – 760002, Orissa, India
CH. NIRANJAN PATRA
; P.G. Department of Pharmaceutics, College of Pharmaceutical Sciences, Berhampur – 760002, Orissa, India
V. JAGANNATH PATRO
; P.G. Department of Pharmaceutics, College of Pharmaceutical Sciences, Berhampur – 760002, Orissa, India
KALYAN KUMAR SEN
; P.G. Department of Pharmaceutics, Gupta College of Pharmaceutical Sciences, Asansol, West Bengal, India
Sažetak
The purpose of the present research work was to observe the effects of drug solubility on the release kinetics of water soluble verapamil hydrochloride and insoluble aceclofenac from polymer based matrix formulations. Matrix formulations were prepared by the direct compression method. The formulations were evaluated for various physical parameters. Along with the dynamics of water uptake and erosion, SEM and in vitro drug release of tablets were studied. Applying an exponential equation, it was found that the kinetics of soluble drug release followed anomalous non-Fickian diffusion transport whereas insoluble drug showed zero-order release. SEM study showed pore formation on the tablet surface that differed depending on drug solubility. t-Test pointed to a significant difference in the amount of both drugs released due to their difference in solubility. Solubility of the drug affects the kinetics and the mechanism of drug release.
Ključne riječi
solubility; release kinetics; swelling; erosion; matrix tablets; statistical analysis
Hrčak ID:
38923
URI
Datum izdavanja:
1.9.2009.
Posjeta: 2.963 *