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Original scientific paper
https://doi.org/10.2478/v10007-009-0024-9

Karakterizacija solvatomorfa metotreksata pomoću termoanalitičkih i drugih metoda

RENU CHADHA ; University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160014, India
POONAM ARORA ; University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160014, India
RUPINDER KAUR ; University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160014, India
ANUPAM SAINI ; University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160014, India
MADAN LAL SINGLA ; Central Scientific Instruments Organization, Sector-30/C, Chandigarh-16003, India
DHARAMVIR SINGH JAIN ; Department of Chemistry, Panjab University, Chandigarh-160014, India

Fulltext: english, pdf (321 KB) pages 245-257 downloads: 1.103* cite
APA 6th Edition
CHADHA, R., ARORA, P., KAUR, R., SAINI, A., SINGLA, M.L. & JAIN, D.S. (2009). Characterization of solvatomorphs of methotrexate using thermoanalytical and other techniques. Acta Pharmaceutica, 59 (3), 245-257. https://doi.org/10.2478/v10007-009-0024-9
MLA 8th Edition
CHADHA, RENU, et al. "Characterization of solvatomorphs of methotrexate using thermoanalytical and other techniques." Acta Pharmaceutica, vol. 59, no. 3, 2009, pp. 245-257. https://doi.org/10.2478/v10007-009-0024-9. Accessed 23 Jul. 2019.
Chicago 17th Edition
CHADHA, RENU, POONAM ARORA, RUPINDER KAUR, ANUPAM SAINI, MADAN LAL SINGLA and DHARAMVIR SINGH JAIN. "Characterization of solvatomorphs of methotrexate using thermoanalytical and other techniques." Acta Pharmaceutica 59, no. 3 (2009): 245-257. https://doi.org/10.2478/v10007-009-0024-9
Harvard
CHADHA, R., et al. (2009). 'Characterization of solvatomorphs of methotrexate using thermoanalytical and other techniques', Acta Pharmaceutica, 59(3), pp. 245-257. https://doi.org/10.2478/v10007-009-0024-9
Vancouver
CHADHA R, ARORA P, KAUR R, SAINI A, SINGLA ML, JAIN DS. Characterization of solvatomorphs of methotrexate using thermoanalytical and other techniques. Acta Pharm. [Internet]. 2009 [cited 2019 July 23];59(3):245-257. https://doi.org/10.2478/v10007-009-0024-9
IEEE
R. CHADHA, P. ARORA, R. KAUR, A. SAINI, M.L. SINGLA and D.S. JAIN, "Characterization of solvatomorphs of methotrexate using thermoanalytical and other techniques", Acta Pharmaceutica, vol.59, no. 3, pp. 245-257, 2009. [Online]. https://doi.org/10.2478/v10007-009-0024-9

Abstracts
U radu je provedena identifikacija i karakterizacija pet različitih formi metotreksata dobivenih kristalizacijom iz različitih otapala. Desolvatacijska izoterma u DSC popraćena gubitkom mase u TGA za forme I, II, IV i V ukazuje da su te forme solvati s acetonitrilom: hidrat (forma I), trihidrat (forma II i IV) i solvat s dimetilformamidom (forma V). Međutim, desolvatacijski pik je odsutan u formi III (dobivenoj iz metanola) što ukazuje na odsutnost otapala u kristalnoj formi. Ta forma je parcijalno kristalna i pokazuje odgovarajući XRPD uzorak. Energija kristalne ćelije je za različite forme različita, što ima za posljedicu različite entalpije otapanja te omogućava primjenu kalorimetrije otopine za diferencijaciju formi. Topljivost je korelirana s entalpijom otopine i kristaliničnosti svih formi. Najmanje endotermna forma (forma III) je najbolje topljiva.

Keywords
solvatomorf; pseudopolimorf; metotreksat; entalija otopine; kalorimetrija otopine; desolvatacija; topljivost

Hrčak ID: 38924

URI
https://hrcak.srce.hr/38924

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