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Acta Pharmaceutica, Vol. 59 No. 3, 2009.

Izvorni znanstveni članak
https://doi.org/10.2478/v10007-009-0024-9

Karakterizacija solvatomorfa metotreksata pomoću termoanalitičkih i drugih metoda

RENU CHADHA ; University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160014, India
POONAM ARORA ; University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160014, India
RUPINDER KAUR ; University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160014, India
ANUPAM SAINI ; University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh-160014, India
MADAN LAL SINGLA ; Central Scientific Instruments Organization, Sector-30/C, Chandigarh-16003, India
DHARAMVIR SINGH JAIN ; Department of Chemistry, Panjab University, Chandigarh-160014, India

Puni tekst: engleski, pdf (321 KB) str. 245-257 preuzimanja: 1.057* citiraj
APA 6th Edition
CHADHA, R., ARORA, P., KAUR, R., SAINI, A., SINGLA, M.L. i JAIN, D.S. (2009). Characterization of solvatomorphs of methotrexate using thermoanalytical and other techniques. Acta Pharmaceutica, 59 (3), 245-257. https://doi.org/10.2478/v10007-009-0024-9
MLA 8th Edition
CHADHA, RENU, et al. "Characterization of solvatomorphs of methotrexate using thermoanalytical and other techniques." Acta Pharmaceutica, vol. 59, br. 3, 2009, str. 245-257. https://doi.org/10.2478/v10007-009-0024-9. Citirano 19.03.2019.
Chicago 17th Edition
CHADHA, RENU, POONAM ARORA, RUPINDER KAUR, ANUPAM SAINI, MADAN LAL SINGLA i DHARAMVIR SINGH JAIN. "Characterization of solvatomorphs of methotrexate using thermoanalytical and other techniques." Acta Pharmaceutica 59, br. 3 (2009): 245-257. https://doi.org/10.2478/v10007-009-0024-9
Harvard
CHADHA, R., et al. (2009). 'Characterization of solvatomorphs of methotrexate using thermoanalytical and other techniques', Acta Pharmaceutica, 59(3), str. 245-257. doi: https://doi.org/10.2478/v10007-009-0024-9
Vancouver
CHADHA R, ARORA P, KAUR R, SAINI A, SINGLA ML, JAIN DS. Characterization of solvatomorphs of methotrexate using thermoanalytical and other techniques. Acta Pharm. [Internet]. 2009 [pristupljeno 19.03.2019.];59(3):245-257. doi: https://doi.org/10.2478/v10007-009-0024-9
IEEE
R. CHADHA, P. ARORA, R. KAUR, A. SAINI, M.L. SINGLA i D.S. JAIN, "Characterization of solvatomorphs of methotrexate using thermoanalytical and other techniques", Acta Pharmaceutica, vol.59, br. 3, str. 245-257, 2009. [Online]. doi: https://doi.org/10.2478/v10007-009-0024-9

Sažetak
U radu je provedena identifikacija i karakterizacija pet različitih formi metotreksata dobivenih kristalizacijom iz različitih otapala. Desolvatacijska izoterma u DSC popraćena gubitkom mase u TGA za forme I, II, IV i V ukazuje da su te forme solvati s acetonitrilom: hidrat (forma I), trihidrat (forma II i IV) i solvat s dimetilformamidom (forma V). Međutim, desolvatacijski pik je odsutan u formi III (dobivenoj iz metanola) što ukazuje na odsutnost otapala u kristalnoj formi. Ta forma je parcijalno kristalna i pokazuje odgovarajući XRPD uzorak. Energija kristalne ćelije je za različite forme različita, što ima za posljedicu različite entalpije otapanja te omogućava primjenu kalorimetrije otopine za diferencijaciju formi. Topljivost je korelirana s entalpijom otopine i kristaliničnosti svih formi. Najmanje endotermna forma (forma III) je najbolje topljiva.

Ključne riječi
solvatomorf; pseudopolimorf; metotreksat; entalija otopine; kalorimetrija otopine; desolvatacija; topljivost

Hrčak ID: 38924

URI
https://hrcak.srce.hr/38924

[engleski]

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