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Acta Pharmaceutica, Vol. 59 No. 3, 2009.

Kratko priopćenje
https://doi.org/10.2478/v10007-009-0021-z

Isporuka tekućeg pripravka H2-antagonista s lokalnim djelovanjem: Primjena tekućeg ljekovitog oblika koji gelira in situ

GANAPATI ROHITH ; Department of Pharmaceutics, National College of Pharmacy, Shimoga 577201, India
BHIMAGONI KESHAVAMURTHY SRIDHAR ; Department of Pharmaceutics, National College of Pharmacy, Shimoga 577201, India
ANEGUNDHA SRINATHA ; Department of Pharmaceutics, National College of Pharmacy, Shimoga 577201, India

Puni tekst: engleski, pdf (82 KB) str. 345-354 preuzimanja: 888* citiraj
APA 6th Edition
ROHITH, G., SRIDHAR, B.K. i SRINATHA, A. (2009). Floating drug delivery of a locally acting H2-antagonist: An approach using an in situ gelling liquid formulation. Acta Pharmaceutica, 59 (3), 345-354. https://doi.org/10.2478/v10007-009-0021-z
MLA 8th Edition
ROHITH, GANAPATI, et al. "Floating drug delivery of a locally acting H2-antagonist: An approach using an in situ gelling liquid formulation." Acta Pharmaceutica, vol. 59, br. 3, 2009, str. 345-354. https://doi.org/10.2478/v10007-009-0021-z. Citirano 27.05.2019.
Chicago 17th Edition
ROHITH, GANAPATI, BHIMAGONI KESHAVAMURTHY SRIDHAR i ANEGUNDHA SRINATHA. "Floating drug delivery of a locally acting H2-antagonist: An approach using an in situ gelling liquid formulation." Acta Pharmaceutica 59, br. 3 (2009): 345-354. https://doi.org/10.2478/v10007-009-0021-z
Harvard
ROHITH, G., SRIDHAR, B.K., i SRINATHA, A. (2009). 'Floating drug delivery of a locally acting H2-antagonist: An approach using an in situ gelling liquid formulation', Acta Pharmaceutica, 59(3), str. 345-354. doi: https://doi.org/10.2478/v10007-009-0021-z
Vancouver
ROHITH G, SRIDHAR BK, SRINATHA A. Floating drug delivery of a locally acting H2-antagonist: An approach using an in situ gelling liquid formulation. Acta Pharm. [Internet]. 2009 [pristupljeno 27.05.2019.];59(3):345-354. doi: https://doi.org/10.2478/v10007-009-0021-z
IEEE
G. ROHITH, B.K. SRIDHAR i A. SRINATHA, "Floating drug delivery of a locally acting H2-antagonist: An approach using an in situ gelling liquid formulation", Acta Pharmaceutica, vol.59, br. 3, str. 345-354, 2009. [Online]. doi: https://doi.org/10.2478/v10007-009-0021-z

Sažetak
U radu je opisana priprava tekućeg pripravka za kontroliranu isporuku ranitidina s produljenim zadržavanjem u želucu. Pripravak gelira in situ, a načinjen je iz natrijeva alginata niske, srednje i visoke viskoznosti, kalcijeva karbonata (izvor kationa) i ranitidina. Pripravcima je ispitana viskoznost, vrijeme plutanja, sadržaj ranitidina i oslobađanje ljekovite tvari in vitro. Koncentracije natrijeva alginata, kalcijeva karbonata i ljekovite tvari značajno utječu na viskoznost, vrijeme plutanja i oslobađanje ranitidina. Utvrđeno je da se ljekovita tvar iz gela oslobađa difuzijom.

Ključne riječi
gastroretencija; in situ geliranje; natrijev alginat; ranitidin

Hrčak ID: 38938

URI
https://hrcak.srce.hr/38938

[engleski]

Posjeta: 1.137 *