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Acta Pharmaceutica, Vol. 59 No. 3, 2009.

Izvorni znanstveni članak
https://doi.org/10.2478/v10007-009-0027-6

Metalloantibiotics: Synthesis, characterization and antimicrobial evaluation of bismuth-fluoroquinolone complexes against Helicobacter pylori

ANWAR R. SHAIKH ; Pharmacy Department, Faculty of Technology and Engineering, The M. S. University of Baroda, Vadodara-390 001, India
RAJANI GIRIDHAR ; Pharmacy Department, Faculty of Technology and Engineering, The M. S. University of Baroda, Vadodara-390 001, India
FRANCIS MEGRAUD ; Laboratoire de Bacteriologie, Université Victor Segalen Bordeaux 2 and Hôpital Pellegrin, Place Amélie Raba-Léon, 33076 Bordeaux cedex, France
MANGE RAM YADAV ; Pharmacy Department, Faculty of Technology and Engineering, The M. S. University of Baroda, Vadodara-390 001, India

Puni tekst: engleski, pdf (179 KB) str. 259-271 preuzimanja: 897* citiraj
APA 6th Edition
SHAIKH, A.R., GIRIDHAR, R., MEGRAUD, F. i YADAV, M.R. (2009). Metalloantibiotics: Synthesis, characterization and antimicrobial evaluation of bismuth-fluoroquinolone complexes against Helicobacter pylori. Acta Pharmaceutica, 59 (3), 259-271. https://doi.org/10.2478/v10007-009-0027-6
MLA 8th Edition
SHAIKH, ANWAR R., et al. "Metalloantibiotics: Synthesis, characterization and antimicrobial evaluation of bismuth-fluoroquinolone complexes against Helicobacter pylori." Acta Pharmaceutica, vol. 59, br. 3, 2009, str. 259-271. https://doi.org/10.2478/v10007-009-0027-6. Citirano 23.02.2019.
Chicago 17th Edition
SHAIKH, ANWAR R., RAJANI GIRIDHAR, FRANCIS MEGRAUD i MANGE RAM YADAV. "Metalloantibiotics: Synthesis, characterization and antimicrobial evaluation of bismuth-fluoroquinolone complexes against Helicobacter pylori." Acta Pharmaceutica 59, br. 3 (2009): 259-271. https://doi.org/10.2478/v10007-009-0027-6
Harvard
SHAIKH, A.R., et al. (2009). 'Metalloantibiotics: Synthesis, characterization and antimicrobial evaluation of bismuth-fluoroquinolone complexes against Helicobacter pylori', Acta Pharmaceutica, 59(3), str. 259-271. doi: https://doi.org/10.2478/v10007-009-0027-6
Vancouver
SHAIKH AR, GIRIDHAR R, MEGRAUD F, YADAV MR. Metalloantibiotics: Synthesis, characterization and antimicrobial evaluation of bismuth-fluoroquinolone complexes against Helicobacter pylori. Acta Pharm. [Internet]. 2009 [pristupljeno 23.02.2019.];59(3):259-271. doi: https://doi.org/10.2478/v10007-009-0027-6
IEEE
A.R. SHAIKH, R. GIRIDHAR, F. MEGRAUD i M.R. YADAV, "Metalloantibiotics: Synthesis, characterization and antimicrobial evaluation of bismuth-fluoroquinolone complexes against Helicobacter pylori", Acta Pharmaceutica, vol.59, br. 3, str. 259-271, 2009. [Online]. doi: https://doi.org/10.2478/v10007-009-0027-6

Sažetak
Novel organometallic compounds have been prepared by complexing the fluoroquinolones, norfloxacin, ofloxacin, ciprofloxacin, sparfloxacin, lomefloxacin, pefloxacin and gatifloxacin, with bismuth. The complexes were characterized by UV, IR, atomic absorption spectroscopy, elemental analysis, differential scanning calorimetry, thermogravimetric analysis and mass spectrometry. Their antibacterial potential against Helicobacter pylori and other microorganisms was investigated. These compounds were found to possess strong activity against Helicobacter pylori at a minimum inhibitory concentration of 0.5 mg Ll. They also exhibited moderate activity against Escherichia coli, Staphylococcus aureus, Bacillus pumilus and Staphylococcus epidermidis. These bismuth-fluoroquinolone complexes have the potential to be developed as drugs against H. pylori related ailments.

Ključne riječi
fluoroquinolone; bismuth; complex; antimicrobial activity; Helicobacter pylory

Hrčak ID: 39122

URI
https://hrcak.srce.hr/39122

[hrvatski]

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