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Seryl-tRNA Synthetases: Enzymes with Multiple Personalities

Silvija Bilokapić ; Department of Chemistry, Faculty of Science, University of Zagreb, Zagreb, Croatia
Nenad Ban ; Institute of Molecular Biology and Biophysics, Swiss Federal Institute of Technology, ETH Zürich, Switzerland
Ivana Weygand-Đurašević ; Department of Chemistry, Faculty of Science, University of Zagreb, Zagreb, Croatia

Puni tekst: engleski, pdf (12 MB) str. 493-501 preuzimanja: 495* citiraj
APA 6th Edition
Bilokapić, S., Ban, N. i Weygand-Đurašević, I. (2009). Seryl-tRNA Synthetases: Enzymes with Multiple Personalities. Croatica Chemica Acta, 82 (2), 493-501. Preuzeto s https://hrcak.srce.hr/39697
MLA 8th Edition
Bilokapić, Silvija, et al. "Seryl-tRNA Synthetases: Enzymes with Multiple Personalities." Croatica Chemica Acta, vol. 82, br. 2, 2009, str. 493-501. https://hrcak.srce.hr/39697. Citirano 07.04.2020.
Chicago 17th Edition
Bilokapić, Silvija, Nenad Ban i Ivana Weygand-Đurašević. "Seryl-tRNA Synthetases: Enzymes with Multiple Personalities." Croatica Chemica Acta 82, br. 2 (2009): 493-501. https://hrcak.srce.hr/39697
Harvard
Bilokapić, S., Ban, N., i Weygand-Đurašević, I. (2009). 'Seryl-tRNA Synthetases: Enzymes with Multiple Personalities', Croatica Chemica Acta, 82(2), str. 493-501. Preuzeto s: https://hrcak.srce.hr/39697 (Datum pristupa: 07.04.2020.)
Vancouver
Bilokapić S, Ban N, Weygand-Đurašević I. Seryl-tRNA Synthetases: Enzymes with Multiple Personalities. Croatica Chemica Acta [Internet]. 2009 [pristupljeno 07.04.2020.];82(2):493-501. Dostupno na: https://hrcak.srce.hr/39697
IEEE
S. Bilokapić, N. Ban i I. Weygand-Đurašević, "Seryl-tRNA Synthetases: Enzymes with Multiple Personalities", Croatica Chemica Acta, vol.82, br. 2, str. 493-501, 2009. [Online]. Dostupno na: https://hrcak.srce.hr/39697. [Citirano: 07.04.2020.]

Sažetak
Seryl-tRNA synthetases (SerRS) are essential enzymes responsible for aminoacylation of cognate transfer-RNAs (tRNAsSer) with serine, which is then incorporated into the proteins being synthesized on the ribosome. Although tRNA synthetases are usually a very conserved class of enzymes, phylogenic analyses revealed the existence of two distinct types of serine-charging enzymes; a standard or bacterial-type SerRS is found in the majority of organisms (prokaryotes, eukaryotes and archaea), while a highly diverged methanogenic-type SerRS is confined to the methanogenic archaea. We give a short overview on our recent biochemical and structural contributions to the understanding of different molecular mecha-nisms of tRNA serylation.

Ključne riječi
seryl-tRNA synthetase; transfer RNA; synthetase crystal structure; synthetase: tRNA model

Hrčak ID: 39697

URI
https://hrcak.srce.hr/39697

Posjeta: 859 *