Izvorni znanstveni članak
Dyslipidemia and Adherence to the Mediterranean Diet in Croatian HIV-Infected Patients during the First Year of Highly Active Antiretroviral Therapy
Drago Turčinov
; University Hospital for Infectious Diseases, Zagreb, Croatia
Christine Stanley
; University of California, San Francisco School of Medicine, San Francisco, California, USA
Jesse A. Canchola
; California State University, East Bay Hayward, California, USA
George W. Rutherford
; University of California, San Francisco School of Medicine, San Francisco, California, USA
Thomas E. Novotny
; University of California, San Francisco School of Medicine, San Francisco, California, USA
Josip Begovac
; University Hospital for Infectious Diseases, Zagreb, Croatia
Sažetak
We investigated the association of adherence to the Mediterranean diet and other risk factors for dyslipidemia in HIV-infected Croatian patients during the first year of highly active antiretroviral therapy (HAART). Adherence to the Mediterranean diet was determined by a 150-item questionnaire; a 0 to 9-point diet scale was created that stratified respondents as having low adherence (<4 points) and moderate to high adherence (ł 4 points). We interviewed 117 participants between May 2004 and June 2005 and abstracted their serum lipid measurements taken during the first year of HAART. The values of total cholesterol, HDL-cholesterol, LDL-cholesterol and triglycerides increased most prominently in the first 3 to 6 months after initiation of HAART (average increase at 3 months: 25% for total cholesterol, 22% for LDL-cholesterol, 18% for HDL-cholesterol and 43% for triglycerides). A Mediterranean diet and physical activity had no effect on serum lipids. The mean total cholesterol was higher in participants receiving a combination of a non-nucleoside reverse transcriptase inhibitor and a protease inhibitor compared to participants receiving a combination of nucleoside analogs with a non-nucleoside analog or a combination of nucleoside analogs and a protease inhibitor. Among individual drug treatments, indinavir/ritonavir had the most unfavorable lipid profile. We conclude that adherence to a Mediterranean diet does not influence serum lipid profiles during the first year of HAART.
Ključne riječi
dyslipidemia; HIV; HAART; Mediterranean diet; physical activity
Hrčak ID:
40521
URI
Datum izdavanja:
1.7.2009.
Posjeta: 1.146 *