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A Comparison of Intramuscular Versus Inhaled Epinephrine in Humans: A Pilot Study

Marcello Augello ; Department of Craniomaxillofacial Surgery, University of Zürich Dental Center, Zürich, Switzerland
Sebastian Kasprzyk ; Department of Craniomaxillofacial Surgery, University of Zürich Dental Center, Zürich, Switzerland
Klaus Willhelm Grätz ; Department of Craniomaxillofacial Surgery, University of Zürich Dental Center, Zürich, Switzerland
Till Sebastian Mutzbauer ; Department of Craniomaxillofacial Surgery, University of Zürich Dental Center, Zürich, Switzerland

Puni tekst: engleski, pdf (449 KB) str. 225-233 preuzimanja: 668* citiraj
APA 6th Edition
Augello, M., Kasprzyk, S., Grätz, K.W. i Mutzbauer, T.S. (2009). A Comparison of Intramuscular Versus Inhaled Epinephrine in Humans: A Pilot Study. Acta stomatologica Croatica, 43 (3), 225-233. Preuzeto s https://hrcak.srce.hr/40782
MLA 8th Edition
Augello, Marcello, et al. "A Comparison of Intramuscular Versus Inhaled Epinephrine in Humans: A Pilot Study." Acta stomatologica Croatica, vol. 43, br. 3, 2009, str. 225-233. https://hrcak.srce.hr/40782. Citirano 22.09.2020.
Chicago 17th Edition
Augello, Marcello, Sebastian Kasprzyk, Klaus Willhelm Grätz i Till Sebastian Mutzbauer. "A Comparison of Intramuscular Versus Inhaled Epinephrine in Humans: A Pilot Study." Acta stomatologica Croatica 43, br. 3 (2009): 225-233. https://hrcak.srce.hr/40782
Harvard
Augello, M., et al. (2009). 'A Comparison of Intramuscular Versus Inhaled Epinephrine in Humans: A Pilot Study', Acta stomatologica Croatica, 43(3), str. 225-233. Preuzeto s: https://hrcak.srce.hr/40782 (Datum pristupa: 22.09.2020.)
Vancouver
Augello M, Kasprzyk S, Grätz KW, Mutzbauer TS. A Comparison of Intramuscular Versus Inhaled Epinephrine in Humans: A Pilot Study. Acta stomatologica Croatica [Internet]. 2009 [pristupljeno 22.09.2020.];43(3):225-233. Dostupno na: https://hrcak.srce.hr/40782
IEEE
M. Augello, S. Kasprzyk, K.W. Grätz i T.S. Mutzbauer, "A Comparison of Intramuscular Versus Inhaled Epinephrine in Humans: A Pilot Study", Acta stomatologica Croatica, vol.43, br. 3, str. 225-233, 2009. [Online]. Dostupno na: https://hrcak.srce.hr/40782. [Citirano: 22.09.2020.]
Puni tekst: hrvatski, pdf (449 KB) str. 225-233 preuzimanja: 412* citiraj
APA 6th Edition
Augello, M., Kasprzyk, S., Grätz, K.W. i Mutzbauer, T.S. (2009). Usporedba intramuskularno primijenjenog i inhaliranog epinefrina: eksperimentalno istraživanje. Acta stomatologica Croatica, 43 (3), 225-233. Preuzeto s https://hrcak.srce.hr/40782
MLA 8th Edition
Augello, Marcello, et al. "Usporedba intramuskularno primijenjenog i inhaliranog epinefrina: eksperimentalno istraživanje." Acta stomatologica Croatica, vol. 43, br. 3, 2009, str. 225-233. https://hrcak.srce.hr/40782. Citirano 22.09.2020.
Chicago 17th Edition
Augello, Marcello, Sebastian Kasprzyk, Klaus Willhelm Grätz i Till Sebastian Mutzbauer. "Usporedba intramuskularno primijenjenog i inhaliranog epinefrina: eksperimentalno istraživanje." Acta stomatologica Croatica 43, br. 3 (2009): 225-233. https://hrcak.srce.hr/40782
Harvard
Augello, M., et al. (2009). 'Usporedba intramuskularno primijenjenog i inhaliranog epinefrina: eksperimentalno istraživanje', Acta stomatologica Croatica, 43(3), str. 225-233. Preuzeto s: https://hrcak.srce.hr/40782 (Datum pristupa: 22.09.2020.)
Vancouver
Augello M, Kasprzyk S, Grätz KW, Mutzbauer TS. Usporedba intramuskularno primijenjenog i inhaliranog epinefrina: eksperimentalno istraživanje. Acta stomatologica Croatica [Internet]. 2009 [pristupljeno 22.09.2020.];43(3):225-233. Dostupno na: https://hrcak.srce.hr/40782
IEEE
M. Augello, S. Kasprzyk, K.W. Grätz i T.S. Mutzbauer, "Usporedba intramuskularno primijenjenog i inhaliranog epinefrina: eksperimentalno istraživanje", Acta stomatologica Croatica, vol.43, br. 3, str. 225-233, 2009. [Online]. Dostupno na: https://hrcak.srce.hr/40782. [Citirano: 22.09.2020.]

Sažetak
Purpose: The intravenous or intramuscular administration of epinephrine is recommended treatment in systemic anaphylaxis. The goal was to evaluate epinephrine plasma levels after intramuscular injection into the buccinator muscle in comparison to inhaled epinephrine. Methods: In this pilot study in humans, we measured plasma epinephrine concentrations before and after epinephrine administration by intramuscular injection, or by inhalation, with intramuscular saline and intravenous epinephrine as the negative and positive controls, respectively. Results: Peak plasma epinephrine concentrations were higher after epinephrine was injected intramuscularly with a maximum plasma epinephrine concentration of 3367.2 pg/ml. After administration by inhalation epinephrine peak level was 151.89 pg/ml. Conclusions: In cases of respiratory distress when anaphylaxis is a possible cause, at first the application of epinephrine by inhalation may be of value. Manifest major cardiovascular reactions according to anaphylaxis without availability of a venous access can only be treated by titration of epinephrine intramuscularly. The buccinator muscle is a useful site for dentists involved on treatment of anaphylaxis.

Ključne riječi
Anaphylaxis; Epinephrine

Hrčak ID: 40782

URI
https://hrcak.srce.hr/40782

[hrvatski]

Posjeta: 1.540 *