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Lamotrigine Therapy for Resistant Pain in Radicular Lesions of Cervical Segments C4-C5 and C5-C6: A Case Report

Marina Titlić
Ivana Jukić
Ante Tonkić
Ante Buča
Anka Aleksić-Shihabi

Puni tekst: engleski, pdf (822 KB) str. 157-160 preuzimanja: 497* citiraj
APA 6th Edition
Titlić, M., Jukić, I., Tonkić, A., Buča, A. i Aleksić-Shihabi, A. (2009). Lamotrigine Therapy for Resistant Pain in Radicular Lesions of Cervical Segments C4-C5 and C5-C6: A Case Report. Acta clinica Croatica, 48 (2), 157-160. Preuzeto s https://hrcak.srce.hr/40952
MLA 8th Edition
Titlić, Marina, et al. "Lamotrigine Therapy for Resistant Pain in Radicular Lesions of Cervical Segments C4-C5 and C5-C6: A Case Report." Acta clinica Croatica, vol. 48, br. 2, 2009, str. 157-160. https://hrcak.srce.hr/40952. Citirano 23.07.2019.
Chicago 17th Edition
Titlić, Marina, Ivana Jukić, Ante Tonkić, Ante Buča i Anka Aleksić-Shihabi. "Lamotrigine Therapy for Resistant Pain in Radicular Lesions of Cervical Segments C4-C5 and C5-C6: A Case Report." Acta clinica Croatica 48, br. 2 (2009): 157-160. https://hrcak.srce.hr/40952
Harvard
Titlić, M., et al. (2009). 'Lamotrigine Therapy for Resistant Pain in Radicular Lesions of Cervical Segments C4-C5 and C5-C6: A Case Report', Acta clinica Croatica, 48(2), str. 157-160. Preuzeto s: https://hrcak.srce.hr/40952 (Datum pristupa: 23.07.2019.)
Vancouver
Titlić M, Jukić I, Tonkić A, Buča A, Aleksić-Shihabi A. Lamotrigine Therapy for Resistant Pain in Radicular Lesions of Cervical Segments C4-C5 and C5-C6: A Case Report. Acta clinica Croatica [Internet]. 2009 [pristupljeno 23.07.2019.];48(2):157-160. Dostupno na: https://hrcak.srce.hr/40952
IEEE
M. Titlić, I. Jukić, A. Tonkić, A. Buča i A. Aleksić-Shihabi, "Lamotrigine Therapy for Resistant Pain in Radicular Lesions of Cervical Segments C4-C5 and C5-C6: A Case Report", Acta clinica Croatica, vol.48, br. 2, str. 157-160, 2009. [Online]. Dostupno na: https://hrcak.srce.hr/40952. [Citirano: 23.07.2019.]

Sažetak
Radicular pain syndromes caused by disk herniation are often accompanied by incomplete central cord syndrome. Intensive pain is difficult to control with standard analgesics. Antiepileptics of new generation have shown significant efficacy in treating pain syndromes, trigeminal neuralgia, diabetic neuropathy, migraines, etc. The treatment of radicular pain with lamotrigine, a new generation antiepileptic, turned out to be effective in lumbar disk radicular conflicts, justifying its application for resistant pain in cervical segment. In our patient, pain intensity was significantly reduced with gradual titration of lamotrigine to a dose of 200 mg/day. Pain intensity measured by the visual analog scale significantly decreased from 100 to 20 mm during eight weeks of titration. The blood concentration of the drug measured by the method of high performance liquid chromatography was 13.65 µmol/L. The patient.s quality of life improved greatly. It is necessary to further evaluate the efficacy of lamotrigine in the treatment of resistant radicular damage.

Ključne riječi
Spinal cord diseases - therapy; Neuralgia - physiopathology; Neuralgia - drug therapy; Anticonvulsants - pharmacology; Pain - drug therapy

Hrčak ID: 40952

URI
https://hrcak.srce.hr/40952

[hrvatski]

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