hrcak mascot   Srce   HID

Recenzija, Prikaz slučaja

Effects of Relapsing-Remitting Multiple Sclerosis Treatment with Interferon Beta-1b Results of a Three-Year Follow-Up Study

Aleksandar Ješić
Dragana Stefanović
Nenad Delibašić
Marija Semnic
Lorand Sakallasz
Dragica Dobrenov
Željko Živanović
Tamara Rabi-Žikić
Milorad Žikić

Puni tekst: engleski, pdf (162 KB) str. 183-186 preuzimanja: 417* citiraj
APA 6th Edition
Ješić, A., Stefanović, D., Delibašić, N., Semnic, M., Sakallasz, L., Dobrenov, D., ... Žikić, M. (2009). Effects of Relapsing-Remitting Multiple Sclerosis Treatment with Interferon Beta-1b Results of a Three-Year Follow-Up Study. Acta clinica Croatica, 48 (2), 183-186. Preuzeto s https://hrcak.srce.hr/40975
MLA 8th Edition
Ješić, Aleksandar, et al. "Effects of Relapsing-Remitting Multiple Sclerosis Treatment with Interferon Beta-1b Results of a Three-Year Follow-Up Study." Acta clinica Croatica, vol. 48, br. 2, 2009, str. 183-186. https://hrcak.srce.hr/40975. Citirano 16.06.2021.
Chicago 17th Edition
Ješić, Aleksandar, Dragana Stefanović, Nenad Delibašić, Marija Semnic, Lorand Sakallasz, Dragica Dobrenov, Željko Živanović, Tamara Rabi-Žikić i Milorad Žikić. "Effects of Relapsing-Remitting Multiple Sclerosis Treatment with Interferon Beta-1b Results of a Three-Year Follow-Up Study." Acta clinica Croatica 48, br. 2 (2009): 183-186. https://hrcak.srce.hr/40975
Harvard
Ješić, A., et al. (2009). 'Effects of Relapsing-Remitting Multiple Sclerosis Treatment with Interferon Beta-1b Results of a Three-Year Follow-Up Study', Acta clinica Croatica, 48(2), str. 183-186. Preuzeto s: https://hrcak.srce.hr/40975 (Datum pristupa: 16.06.2021.)
Vancouver
Ješić A, Stefanović D, Delibašić N, Semnic M, Sakallasz L, Dobrenov D i sur. Effects of Relapsing-Remitting Multiple Sclerosis Treatment with Interferon Beta-1b Results of a Three-Year Follow-Up Study. Acta clinica Croatica [Internet]. 2009 [pristupljeno 16.06.2021.];48(2):183-186. Dostupno na: https://hrcak.srce.hr/40975
IEEE
A. Ješić, et al., "Effects of Relapsing-Remitting Multiple Sclerosis Treatment with Interferon Beta-1b Results of a Three-Year Follow-Up Study", Acta clinica Croatica, vol.48, br. 2, str. 183-186, 2009. [Online]. Dostupno na: https://hrcak.srce.hr/40975. [Citirano: 16.06.2021.]

Sažetak
The aim of this prospective study was to evaluate therapeutic effects in a cohort of 32 patients with relapsing-remitting multiple sclerosis (RRMS) that were continuously treated with interferon beta-1b during a three-year period and to compare the results obtained with literature data available. Additionally, dropouts and side effects were assessed. The annual relapse rate at three years of treatment as the primary study end-point decreased by 60.5% compared with the relapse rate throughout the pretherapeutic course of disease (0.39±0.55 vs. 0.97±0.46; P<0.001) and by 71.3% compared with the relapse rate one year prior to treatment (0.39±0.55 vs. 1.34±0.65; P<0.001). The mean Extended Disability Status Scale (EDSS) increased significantly from 2.46±0.86 at baseline to 2.90±1.30 (P<0.01) at three years of treatment, whereas the mean progression index (EDSS/disease duration) decreased significantly from 0.76±0.50 prior to treatment to 0.43±0.24 (P <0.001), yielding a 56.6% improvement and proving the disease modifying effect of interferon beta-1b. Seventeen (53.12%) patients remained relapse-free during the course of therapy. Among patients that experienced disease relapse, the mean time to first exacerbation was 11.5±8.34 months. Our study results were consistent with similar studies performed worldwide, clearly indicating that Interferon beta-1b therapy decreased the disease activity and had a beneficial effect on the progression of RRMS, with low incidence and severity of serious side effects. This study has paved way for further long-term follow up studies at our institution.

Ključne riječi
Multiple sclerosis - drug therapy; Interferon-beta - therapeutic use; Adjuvants - immunologic therapeutic use; Follow up studies

Hrčak ID: 40975

URI
https://hrcak.srce.hr/40975

[hrvatski]

Posjeta: 1.073 *