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Arhiv za higijenu rada i toksikologiju, Vol. 57 No. 2, 2006.

Stručni rad

Pyridinium, Imidazolium and Quinuclidinium Compounds: Toxicity and Antidotal Effects against the Nerve Agents Tabun and Soman

Elsa Reiner
Vera Simeon-Rudolf

Puni tekst: engleski, pdf (107 KB) str. 171-179 preuzimanja: 648* citiraj
APA 6th Edition
Reiner, E. i Simeon-Rudolf, V. (2006). Pyridinium, Imidazolium and Quinuclidinium Compounds: Toxicity and Antidotal Effects against the Nerve Agents Tabun and Soman. Arhiv za higijenu rada i toksikologiju, 57 (2), 171-179. Preuzeto s https://hrcak.srce.hr/3926
MLA 8th Edition
Reiner, Elsa i Vera Simeon-Rudolf. "Pyridinium, Imidazolium and Quinuclidinium Compounds: Toxicity and Antidotal Effects against the Nerve Agents Tabun and Soman." Arhiv za higijenu rada i toksikologiju, vol. 57, br. 2, 2006, str. 171-179. https://hrcak.srce.hr/3926. Citirano 23.02.2019.
Chicago 17th Edition
Reiner, Elsa i Vera Simeon-Rudolf. "Pyridinium, Imidazolium and Quinuclidinium Compounds: Toxicity and Antidotal Effects against the Nerve Agents Tabun and Soman." Arhiv za higijenu rada i toksikologiju 57, br. 2 (2006): 171-179. https://hrcak.srce.hr/3926
Harvard
Reiner, E., i Simeon-Rudolf, V. (2006). 'Pyridinium, Imidazolium and Quinuclidinium Compounds: Toxicity and Antidotal Effects against the Nerve Agents Tabun and Soman', Arhiv za higijenu rada i toksikologiju, 57(2), str. 171-179. Preuzeto s: https://hrcak.srce.hr/3926 (Datum pristupa: 23.02.2019.)
Vancouver
Reiner E, Simeon-Rudolf V. Pyridinium, Imidazolium and Quinuclidinium Compounds: Toxicity and Antidotal Effects against the Nerve Agents Tabun and Soman. Arh Hig Rada Toksikol. [Internet]. 2006 [pristupljeno 23.02.2019.];57(2):171-179. Dostupno na: https://hrcak.srce.hr/3926
IEEE
E. Reiner i V. Simeon-Rudolf, "Pyridinium, Imidazolium and Quinuclidinium Compounds: Toxicity and Antidotal Effects against the Nerve Agents Tabun and Soman", Arhiv za higijenu rada i toksikologiju, vol.57, br. 2, str. 171-179, 2006. [Online]. Dostupno na: https://hrcak.srce.hr/3926. [Citirano: 23.02.2019.]

Sažetak
This paper discusses the toxicity and antidotal effects of 32 compounds. Screening studies have shown that these compounds combined with atropine are effective antidotes against the organophosphate nerve agents Tabun and/or Soman, having a therapeutic factor equal or greater than 2.0 when tested in mice or rats. We analysed the results of these studies, and recommend that these compounds should be studied in more detail simultaneously with conventional antidotes (PAM-2, HI-6, Toxogonin, TMB-4) in order to assess whether they could broaden the choice of compounds now available for the treatment of organophosphate poisoning.

Ključne riječi
antidotal effects; experimental poisoning; imidazolium; nerve agents; oximes; organophosphates; pyridinium; quinuclidinium compounds; soman; tabun; therapeutic factors; toxicity

Hrčak ID: 3926

URI
https://hrcak.srce.hr/3926

[hrvatski]

Posjeta: 985 *